An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles

Scholarly Works

• Elinson, M. N.; Vereshchagin, A. N.; Ryzhkova, Y. E.; Karpenko, K. A.; Iliyasov, T. M.; Kalashnikova, V. M.; Egorov, M. P. Multicomponent synthesis of new barbituric acid derivatives. Russian Chemical Bulletin 2024, 73, 1286–1296. doi:10.1007/s11172-024-4245-3
• Luo, J.; Zhou, Q.; Xu, Z.; Houk, K. N.; Zheng, K. Photochemical Skeletal Editing of Pyridines to Bicyclic Pyrazolines and Pyrazoles. Journal of the American Chemical Society 2024. doi:10.1021/jacs.4c03713
• Sun, Y.; Chen, J.; Zhang, M. Iridium-catalyzed reductive β-alkylation of (iso)quinoline derivatives by an in situ enone-trapping strategy. Organic & biomolecular chemistry 2024, 22, 4516–4520. doi:10.1039/d4ob00666f
• Sharma, S.; Gallou, F.; Handa, S. Towards a sustainable tomorrow: advancing green practices in organic chemistry. Green Chemistry 2024, 26, 6289–6317. doi:10.1039/d4gc01826e
• Ghiazza, C.; Moreau, X. Modern Dearomative Enlargement of Heteroaromatic Rings. Synthesis 2024. doi:10.1055/a-2335-8799
• Songsermsawad, S.; Shemchuk, O.; Robeyns, K.; Collard, L.; E Flood, A.; Leyssens, T. Simultaneously resolving BINOL and proline using a stoichiometric cocrystal switch. Chemical communications (Cambridge, England) 2024. doi:10.1039/d4cc02180k
• Zukic, E.; Mokos, D.; Weber, M.; Stix, N.; Ditrich, K.; Ferrario, V.; Müller, H.; Willrodt, C.; Gruber, K.; Daniel, B.; Kroutil, W. Biocatalytic Heteroaromatic Amide Formation in Water Enabled by a Catalytic Tetrad and Two Access Tunnels. ACS catalysis 2024, 14, 8913–8921. doi:10.1021/acscatal.4c01268
• Guo, S.-M.; Xu, P.; Studer, A. Meta-Selective Copper-Catalyzed C-H Arylation of Pyridines and Isoquinolines through Dearomatized Intermediates. Angewandte Chemie (International ed. in English) 2024, 63, e202405385. doi:10.1002/anie.202405385
• Guo, S.; Xu, P.; Studer, A. Meta‐Selective Copper‐Catalyzed C−H Arylation of Pyridines and Isoquinolines through Dearomatized Intermediates. Angewandte Chemie 2024, 136. doi:10.1002/ange.202405385
• Han, H.; Qin, Y.; Wang, F.; Ding, N.; Fang, F.; Hu, L.; Jin, H.; Zhang, Y. Two-Step Synthesis of 4-Hydroxy-3,5-dimethylphenyl Benzoate: Undergraduate Organic Laboratory of Electrophilic Aromatic Substitution and Nucleophilic Aromatic Substitution. Journal of Chemical Education 2024, 101, 2406–2412. doi:10.1021/acs.jchemed.3c01270
• Ryabukhin, S. V.; Bondarenko, S. S.; Fedorchenko, A. M.; Novosolov, P. O.; Marchenko, O. V.; Hanopolskyi, A. I.; Volovenko, Y. M.; Volochnyuk, D. M. Multigram Synthesis of 4,4-Disubstituted 3-Oxopyrrolidones: Efficient Starting Materials for Diverse 3-Functionalized Pyrrolidones. Synlett 2024. doi:10.1055/a-2320-8362
• Alizadeh, V.; Garcia-Santos, I.; Castiñeiras, A.; Mahmoudi, G.; Safin, D. A. A pyrazinamide-benzenesulfonohydrazide hybrid N'-(phenylsulfonyl)pyrazine-2-carbohydrazonamide: Experimental and theoretical insights. Tetrahedron 2024, 162, 134066. doi:10.1016/j.tet.2024.134066
• Zeng, Z.; Qin, S.; Yang, M.; Xu, M.; Peng, Z.-H.; Cai, J.; Wang, S.; Gao, H.; Zhou, Z.; Hashmi, A. S. K.; Yi, W. Electrochemical meta-C−H Sulfonylation of Pyridines with Nucleophilic Sulfinates. Research Square Platform LLC 2024. doi:10.21203/rs.3.rs-4243094/v1
• Zhang, X.; Li, S.; Qiu, F.; Ang, H. T.; Wu, J.; Jia, P. Photocatalyzed Minisci-type reactions for late-stage functionalization of pharmaceutically relevant compounds. Green Chemistry 2024, 26, 3595–3626. doi:10.1039/d3gc05089k
• Dehghany, M.; Pavaneli, G.; Kailing, J. W.; Duke, O. M.; Guzei, I. A.; Da Ros Montes D'Oca, C.; Fernández, I.; Schomaker, J. M. Tunable Divergent Reactivity of Aziridinium Ylides in the Synthesis of Complex Piperidines and Azetidines. ACS Catalysis 2024, 14, 5795–5803. doi:10.1021/acscatal.3c06173
• Cesarini, S.; Vicenti, I.; Poggialini, F.; Filippi, S.; Mancin, E.; Fiaschi, L.; De Marchi, E.; Giammarino, F.; Vagaggini, C.; Bizzarri, B. M.; Saladino, R.; Dreassi, E.; Zazzi, M.; Botta, L. Serendipitous Identification of Azine Anticancer Agents Using a Privileged Scaffold Morphing Strategy. Molecules (Basel, Switzerland) 2024, 29, 1452. doi:10.3390/molecules29071452
• Sunny, S.; Maingle, M.; Sheeba, L.; Pathan, F. R.; J., G. S.; Juloori, H.; Gadewar, S. G.; Seth, K. Cu(ii)-catalyzed 'in-water' N-arylation of electron-deficient NH-heterocycles. Green Chemistry 2024, 26, 3149–3158. doi:10.1039/d3gc05163c
• Jia, H.; Tan, Z.; Zhang, M. Reductive Functionalization of Pyridine-Fused N-Heteroarenes. Accounts of chemical research 2024, 57, 795–813. doi:10.1021/acs.accounts.4c00009
• Javahershenas, R.; Makarem, A.; Klika, K. D. Recent advances in microwave-assisted multicomponent synthesis of spiro heterocycles. RSC advances 2024, 14, 5547–5565. doi:10.1039/d4ra00056k
• Liandi, A. R.; Cahyana, A. H.; Alfariza, D. N.; Nuraini, R.; Sari, R. W.; Wendari, T. P. Spirooxindoles: Recent report of green synthesis approach. Green Synthesis and Catalysis 2024, 5, 1–13. doi:10.1016/j.gresc.2023.08.001

Explore citations to this article at