Efficient synthesis of dihydropyrimidinones via a three-component Biginelli-type reaction of urea, alkylaldehyde and arylaldehyde

Scholarly Works

• Kaur, N. Six-membered N,N-, N,N,N-, and N,N,N,N-heterocycles. Iodine-Assisted Synthesis of Six- and Seven-Membered Heterocycles; Elsevier, 2023; pp 147–174. doi:10.1016/b978-0-443-15225-2.00012-8
• del Corte, X.; Martínez de Marigorta, E.; Palacios, F.; Vicario, J.; Maestro, A. An overview of the applications of chiral phosphoric acid organocatalysts in enantioselective additions to CO and CN bonds. Organic Chemistry Frontiers 2022, 9, 6331–6399. doi:10.1039/d2qo01209j
• Sánchez-Sancho, F.; Escolano, M.; Gaviña, D.; Csáky, A. G.; Sánchez-Roselló, M.; Díaz-Oltra, S.; Del Pozo, C. Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions. Pharmaceuticals (Basel, Switzerland) 2022, 15, 948. doi:10.3390/ph15080948
• Das, D.; Saha, M.; Das, A. R. Synthesis, properties and catalysis of quantum dots in C–C and C-heteroatom bond formations. Physical Sciences Reviews 2022, 8, 4253–4324. doi:10.1515/psr-2021-0093
• Patel, A.; Gandhi, K.; Shah, S.; Patel, D.; Chhatbar, S.; Shah, D.; Patel, S.; Patel, H.; Bambharoliya, T. In silico Study and Solvent-free one-pot Synthesis of Tetrahydropyrimidine derivatives by Mechanochemistry Approach for Targeting Human Neutrophil Elastase against Lung Cancer. Current computer-aided drug design 2022, 18, 293–306. doi:10.2174/1573409918666220622232501
• Boëtius, M. E.; Ruijter, E. doi:10.1002/9783527832439.ch12
• Soccio, M.; Mazzoni, R.; Lucarelli, C.; Quattrosoldi, S.; Cingolani, A.; Fiorini, M.; Lotti, N.; Tabanelli, T. Urea and Polyurea Production: An Innovative Solvent- and Catalyst-Free Approach through Catechol Carbonate. ACS Sustainable Chemistry & Engineering 2020, 8, 15640–15650. doi:10.1021/acssuschemeng.0c05177
• Moumita, S.; Asish, R. D. Nanocrystalline ZnO: A Competent and Reusable Catalyst for the Preparation of Pharmacology Relevant Heterocycles in the Aqueous Medium. Current Green Chemistry 2020, 7, 53–104. doi:10.2174/2213346107666200218122718
• Lopez-Prado, M. V.; Sabater, M. J.; Corma, A. A Bifunctional Metal/Acid Catalyst for One-Pot Multistep Synthesis of Pharmaceuticals. Petroleum Chemistry 2020, 60, 499–507. doi:10.1134/s0965544120040106
• Moussa, S. b.; Mehri, A.; Badraoui, B. Magnesium modified calcium hydroxyapatite: An efficient and recyclable catalyst for the one-pot Biginelli condensation. Journal of Molecular Structure 2020, 1200, 127111. doi:10.1016/j.molstruc.2019.127111
• Heravi, M. M.; Zadsirjan, V. Asymmetric multicomponent reactions. Recent Advances in Applications of Name Reactions in Multicomponent Reactions; Elsevier, 2020; pp 383–422. doi:10.1016/b978-0-12-818584-1.00005-7
• Portilla-Zuñiga, O. M.; Sathicq, A. G.; Martínez, J. J.; Fernandes, S. A.; Rezende, T. R. M.; Romanelli, G. P. Synthesis of Biginelli adducts using a Preyssler heteropolyacid in silica matrix from biomass building block. Sustainable Chemistry and Pharmacy 2018, 10, 50–55. doi:10.1016/j.scp.2018.09.002
• de Oliveira Alvim, H. G.; Pinheiro, D. L. J.; Carvalho-Silva, V. H.; Fioramonte, M.; Gozzo, F. C.; Silva, W. A.; Amarante, G. W.; Neto, B. A. D. Combined Role of the Asymmetric Counteranion-Directed Catalysis (ACDC) and Ionic Liquid Effect for the Enantioselective Biginelli Multicomponent Reaction. The Journal of organic chemistry 2018, 83, 12143–12153. doi:10.1021/acs.joc.8b02101
• Heravi, M. M.; Moradi, R.; Mohammadkhani, L.; Moradi, B. Current progress in asymmetric Biginelli reaction: an update. Molecular diversity 2018, 22, 751–767. doi:10.1007/s11030-018-9841-4
• Tiwari, L.; Kumar, V.; Kumar, B.; Mahajan, D. A practically simple, catalyst free and scalable synthesis of N-substituted ureas in water. RSC advances 2018, 8, 21585–21595. doi:10.1039/c8ra03761b
• Fan, W.; Queneau, Y.; Popowycz, F. HMF in multicomponent reactions: utilization of 5-hydroxymethylfurfural (HMF) in the Biginelli reaction. Green Chemistry 2018, 20, 485–492. doi:10.1039/c7gc03425c
• Said, M.; Eldehna, W. M.; Ghabbour, H. A.; Kabil, M. M.; Al-Shakliah, N. S.; Abdel-Aziz, H. A. Solvent-Free Ring Cleavage Hydrazinolysis of Certain Biginelli Pyrimidines. Journal of Chemistry 2018, 2018, 1–6. doi:10.1155/2018/6354742
• Moussa, S. B.; Lachheb, J.; Gruselle, M.; Maaten, B.; Kriis, K.; Kanger, T.; Tõnsuaadu, K.; Badraoui, B. Calcium, Barium and Strontium apatites: A new generation of catalysts in the Biginelli reaction. Tetrahedron 2017, 73, 6542–6548. doi:10.1016/j.tet.2017.09.051
• Tamuli, K. J.; Dutta, D.; Nath, S.; Bordoloi, M. A Greener and Facile Synthesis of Imidazole and Dihydropyrimidine Derivatives under Solvent‐Free Condition Using Nature‐Derived Catalyst. ChemistrySelect 2017, 2, 7787–7791. doi:10.1002/slct.201701487
• M’hamed, M. O.; Alshammari, A. G.; Lemine, O. Green High-Yielding One-Pot Approach to Biginelli Reaction under Catalyst-Free and Solvent-Free Ball Milling Conditions. Applied Sciences 2016, 6, 431. doi:10.3390/app6120431

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