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Beilstein J. Org. Chem. 2014, 10, 3087–3096, doi:10.3762/bjoc.10.325
Graphical Abstract
Scheme 1: Synthesis of azido functionalized DIMEB 1a. a) Ba(OH)2·8H2O/BaO/Me2SO4
Figure 1: ESI mass spectrum of azido functionalized DIMEB 1a.
Figure 2: 1H NMR spectra of a) 1a, b) 2, and c) 5a.
Scheme 2: Synthesis of propargylated HES 2.
Scheme 3: Synthesis of 5a by [2 + 3] cycloadditon, a) CuSO4, ascorbate, 50 °C, 48 h.
Figure 3: Viabilities of Caco-2 cells incubated with a) 5a after 2 h, b) 5a after 24 h, c) DIMEB after 2 h, d...
Scheme 4: Structures of a) midazolam and b) sevoflurane.