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1 article(s) from El Rhaz, Ahmed

Photoswitchable glycoligands targeting Pseudomonas aeruginosa LecA

Yu Fan,
Ahmed El Rhaz,
Stéphane Maisonneuve,
Emilie Gillon,
Maha Fatthalla,
Franck Le Bideau,
Guillaume Laurent,
Samir Messaoudi,
Anne Imberty and
Juan Xie

Beilstein J. Org. Chem. 2024, 20, 1486–1496, doi:10.3762/bjoc.20.132

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Figure 1: (A) Selected monovalent inhibitors for PA LecA and (B) designed general structure of photoswitchabl...

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Scheme 1: Synthesis of photoswitchable LecA inhibitors. Reagents and conditions: (i) DMC, Et₃N, H₂O, −10 °C t...

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Figure 2: (Left) Absorption spectra and (right) fatigue resistance of 1 under alternated 370/485 nm irradiati...

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Figure 3: ¹H NMR (400 MHz) spectra of E-1 (black line), PSS₃₇₀ (red line), PSS₄₈₅ (blue line) in D₂O/DMSO-d₆ ...

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Figure 4: ITC titration of LecA with E- (up) and Z-isomers (bottom) of compounds 1–5 in Tris buffer containin...

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Figure 5: (A) Enthalpy–entropy compensation plot of compounds 1–5 from ITC analysis. The dotted green line re...

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Published 03 Jul 2024

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