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Beilstein J. Org. Chem. 2024, 20, 101–117, doi:10.3762/bjoc.20.11
Graphical Abstract
Scheme 1: Photoinduced formation of benzo[c]quinolizinium and its interaction with DNA upon intercalation.
Scheme 2: Synthesis of styrylpyridine derivatives 2a–g. Conditions: i: piperidine, MeOH, reflux (2a,c), ii: C...
Figure 1: Absorption spectra of styrylpyridine derivatives 2a (black), 2b (red), 2c (blue), 2d (green), 2e (m...
Figure 2: Changes of the absorption spectra during the irradiation of 2a in MeCN for 16 min (A), 2b in MeCN f...
Figure 3: Changes of the absorption spectra during the irradiation of 2c for 13 min (A), 2d for 12 min (B), 2e...
Scheme 3: Photoinduced formation of styrylpyridine derivatives 2b–g to the benzo[c]quinolizinium ions 3b–g (y...
Figure 4: Photometric titration of ct DNA to 3c (A) 3e (B) 3f (C) and 3g (D) (c = 20 µM) in Na phosphate buff...
Figure 5: Fluorimetric titration of ct DNA to 3c (A), 3e (B), 3f (C), and 3g (D) (c = 20 µM) in Na phosphate ...
Figure 6: CD (A) and LD (B) spectra of 3f and ct DNA (cDNA = 20 µM) in Na phosphate buffer (pH 7.0, T = 20 °C...
Figure 7: Changes of the absorption (A) and CD (B) spectra during the irradiation of 2e (1) and 2f (2) (c = 2...
Scheme 4: Proposed mechanisms for the photoinduced DNA damage initiated by photoexcitation of benzoquinolizin...