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Beilstein J. Org. Chem. 2024, 20, 2005–2015, doi:10.3762/bjoc.20.176
Graphical Abstract
Figure 1: E–Z isomerisation of (a) AzoTAB and (b) AAPTAB under UV light (365 nm) results in a change in shape...
Figure 2: SAXS curves for AzoTAB (50 mM in water) showing the transition from the Z-rich PSS to the E-rich st...
Figure 3: SAXS curves for the Z-rich PSS of AAPTAB (50 mM) in (a) water (H2O) and (b) deuterium dioxide (D2O)...
Figure 4: Addition of excess acid (pH = 0.4) induces Z–E isomerisation in AzoTAB and AAPTAB. UV–vis absorbanc...
Figure 5: Effect of X-ray exposure time on high-concentration samples of AAPTAB in water, (a) 10 wt % and (b)...
Beilstein J. Org. Chem. 2019, 15, 2753–2764, doi:10.3762/bjoc.15.266
Figure 1: a) Tetra ortho-substituted azobenzenes represent a significant advance in terms of Z-isomer stabili...
Figure 2: Minimum-energy geometry calculated for a) the Z-isomer ground state and b) the transition states wi...
Figure 3: Noncovalent index (NCI) surfaces calculated for representative pyrrolidine-based ortho-substituted ...
Figure 4: Noncovalent index (NCI) surfaces and θ dihedral angles (in red) calculated for the minimum-energy g...
Figure 5: Description of the lowest-lying n–π* excitation for the Z-isomers of halogenated 4pzH-F2 and 4pzH-C...
Figure 6: Description of the lowest-lying n–π* excitation for the E-isomers of halogenated 4pzH-F2 and 4pzH-C...
Figure 7: X-ray structures of 4pzMe-F2 (left), 4pzH-F2 (middle) and 4pzMe-OMe2 (right).
Figure 8: Experimental UV–vis spectra of 4pzMe-F2, 4pzMe-Cl2, 4pzMe-OMe2 and 4pzH-F2 in MeCN at 25 µM.
Beilstein J. Org. Chem. 2013, 9, 81–88, doi:10.3762/bjoc.9.11
Figure 1: FDA approved HDAC inhibitors for the treatment of CTCL.
Scheme 1: SAR of psammaplin A against zinc-dependant HDACs. Adapted from Baud et al. [20].
Scheme 2: Synthesis of 7–9. Conditions: (i) HCl·H2NOMe, pyridine, rt, 12 h; (ii) EDC, NHS, dioxane, rt, 3 h; ...
Scheme 3: Top: Generation of the fluorescent adduct 11 after reaction of probe 10 with thiols. Bottom left: F...
Figure 2: rHDAC1 was incubated with a predetermined IC50 concentration of 7 (left) and 9 (right) for 1–60 min...