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Beilstein J. Org. Chem. 2024, 20, 1486–1496, doi:10.3762/bjoc.20.132
Graphical Abstract
Figure 1: (A) Selected monovalent inhibitors for PA LecA and (B) designed general structure of photoswitchabl...
Scheme 1: Synthesis of photoswitchable LecA inhibitors. Reagents and conditions: (i) DMC, Et3N, H2O, −10 °C t...
Figure 2: (Left) Absorption spectra and (right) fatigue resistance of 1 under alternated 370/485 nm irradiati...
Figure 3: 1H NMR (400 MHz) spectra of E-1 (black line), PSS370 (red line), PSS485 (blue line) in D2O/DMSO-d6 ...
Figure 4: ITC titration of LecA with E- (up) and Z-isomers (bottom) of compounds 1–5 in Tris buffer containin...
Figure 5: (A) Enthalpy–entropy compensation plot of compounds 1–5 from ITC analysis. The dotted green line re...
Beilstein J. Org. Chem. 2024, 20, 306–320, doi:10.3762/bjoc.20.31
Figure 1: Characterizing a new lectin from the melon Cucumis melo. (a) Evolutionary relationships of common R...
Figure 2: Characterizing the binding specificity of CMA1. (a, b) Lectin produced in mammalian cells was analy...
Figure 3: Assessing and quantifying in-solution binding of CMA1. (a) Erythrocyte agglutination assay. Using r...
Figure 4: Structural insights into the binding mechanism of CMA1. (a, b) Overall representation of the N-term...