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1 article(s) from He, Hongjian

Enzyme-instructed morphological transition of the supramolecular assemblies of branched peptides

Dongsik Yang,
Hongjian He and
Bing Xu

Beilstein J. Org. Chem. 2020, 16, 2709–2718, doi:10.3762/bjoc.16.221

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Graphical Abstract

Figure 1: A) The molecular structures of the branched peptides Nap-ffk(NH₂-DEDDDLLIG)y (1) and Nap-ffk(AcNH-D...

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Scheme 1: Synthetic route to the branched peptides. (i) HBTU, DIPEA, DMF, 12 h, rt, (ii) TFA, 2 h, rt, and (i...

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Figure 2: A) LC–MS spectrum of the proteolytic products after 1 (5 mM) was incubated with proteinase K (5 U/m...

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Figure 3: Optical images of solutions of 1 and 2 (5 mM), respectively, with or without proteinase K (5 U/mL) ...

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Figure 4: TEM images of the branched peptides before and after the addition of proteinase K into the solution...

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Figure 5: Cell viability of HeLa and Saos-2 cells treated with 1 (A) and 2 (B).

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Figure 6: Confocal images of HeLa cells treated with a mixture of RPE (8 μg/mL) and A) 1 (400 μM) or B) 2 (40...

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Published 04 Nov 2020

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