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Beilstein J. Org. Chem. 2024, 20, 1486–1496, doi:10.3762/bjoc.20.132
Graphical Abstract
Figure 1: (A) Selected monovalent inhibitors for PA LecA and (B) designed general structure of photoswitchabl...
Scheme 1: Synthesis of photoswitchable LecA inhibitors. Reagents and conditions: (i) DMC, Et3N, H2O, −10 °C t...
Figure 2: (Left) Absorption spectra and (right) fatigue resistance of 1 under alternated 370/485 nm irradiati...
Figure 3: 1H NMR (400 MHz) spectra of E-1 (black line), PSS370 (red line), PSS485 (blue line) in D2O/DMSO-d6 ...
Figure 4: ITC titration of LecA with E- (up) and Z-isomers (bottom) of compounds 1–5 in Tris buffer containin...
Figure 5: (A) Enthalpy–entropy compensation plot of compounds 1–5 from ITC analysis. The dotted green line re...
Beilstein J. Org. Chem. 2016, 12, 2828–2833, doi:10.3762/bjoc.12.282
Figure 1: Alkylseleno glycosides, such as 1, are used as tools for X-ray crystallography of lectins. Some lec...
Scheme 1: Synthesis of 3 through initial introduction of the seleno aglycon and subsequent O-methylation. Rea...
Scheme 2: Synthesis of compound 3 via initial selective 2-O-methylation followed by the introduction of the s...
Beilstein J. Org. Chem. 2014, 10, 1981–1990, doi:10.3762/bjoc.10.206
Figure 1: Previously reported low-valent glycoasterisk α-D-Man ligand based on a persulfurated benzene core [30] ...
Scheme 1: Synthesis of trivalent trithiotriazine-based glycoclusters.
Scheme 2: Synthesis of mixed triazine-based glycoclusters.
Figure 2: Dynamic light scattering experiments of bis-D-galactosyl proparyl cluster 16 with lecA. Distributio...
Figure 3: Typical ITC measurements representing the raw ITC data (top) and integrated titration curves (botto...
Figure 4: Inhibition of PAO1 biofilm formation by D-galactose cluster 1, L-fucose cluster 14, and D-glucose c...