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Beilstein J. Org. Chem. 2024, 20, 675–683, doi:10.3762/bjoc.20.61
Graphical Abstract
Scheme 1: Approaches for quinazoline modifications at the C2 and C4 positions.
Scheme 2: Attempts toward sulfonyl group dance using 2,4-dichloroquinazolines 1a‒c.
Scheme 3: Synthesis of 2-chloro-6,7-dimethoxy-4-sulfonylquinazoline derivatives 8.
Scheme 4: Alternative synthesis pathway for 2-chloro-6,7-dimethoxy-4-sulfonylquinazoline derivatives 8.
Scheme 5: Sulfonyl group dance using 2-chloro-6,7-dimethoxy-4-sulfonylquinazolines 8.
Scheme 6: One-pot synthesis of 4-azido-6,7-dimethoxy-2-sulfonylquinazolines 12. The crystallographic informat...
Scheme 7: Synthesis of 2-azido-4-sulfonyl-6,7-dimethoxyquinazolines 15.
Scheme 8: Synthesis of 6,7-dimethoxyquinazoline derivatives 16, 17a and 18.
Scheme 9: Synthesis of 2-amino-4-azido-6,7-dimethoxyquinazolines 17.
Scheme 10: Synthesis of terazosin and prazosin hydrochlorides 19a and 19b.
Scheme 11: Modifications of derivatives 17.