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Beilstein J. Org. Chem. 2018, 14, 2106–2111, doi:10.3762/bjoc.14.185
Graphical Abstract
Figure 1: Hyperireflexolide A.
Scheme 1: Retrosynthetic strategy.
Scheme 2: Hydrolysis of dimethyl ketal 5.
Scheme 3: Alkylation of γ-lactone-fused β-ketoester 6.
Scheme 4: Synthesis of α,β-unsaturated ketone 11.