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1 article(s) from Thong, Nguyen Minh

4-(1-Methylamino)ethylidene-1,5-disubstituted pyrrolidine-2,3-diones: synthesis, anti-inflammatory effect and in silico approaches

Nguyen Tran Nguyen,
Vo Viet Dai,
Luc Van Meervelt,
Do Thi Thao and
Nguyen Minh Thong

Beilstein J. Org. Chem. 2025, 21, 817–829, doi:10.3762/bjoc.21.65

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Graphical Abstract

Figure 1: Natural products and synthetic medicinal compounds containing a 2-pyrrolidinone subunit.

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Scheme 1: Synthesis of 4-[1-(4-methoxybenzyl)amino]ethylidene-1,5-disubstituted pyrrolidine-2,3-diones 3a–e.

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Scheme 2: Synthesis of 4-(1-methylamino)ethylidene-1,5-disubstituted pyrrolidine-2,3-diones 5a–e.

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Scheme 3: Proposed mechanism for the reaction between 4-[1-(4-methoxybenzyl)amino]ethylidene-1,5-disubstitute...

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Figure 2: The molecular structure of 5a, showing the atom-labelling scheme and displacement ellipsoids at the...

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Figure 3: The bioavailability radar of studied compounds 5a–e.

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Figure 4: The interactions of potential drugs 5a–c in the active site of enzyme iNOS.

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Figure 5: The interactions of potential drugs 5d and 5e and control drug (DEX) in the active site of enzyme i...

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Published 24 Apr 2025

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