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1 article(s) from Wiest, Andreas

Improved deconvolution of natural products’ protein targets using diagnostic ions from chemical proteomics linkers

Andreas Wiest and
Pavel Kielkowski

Beilstein J. Org. Chem. 2024, 20, 2323–2341, doi:10.3762/bjoc.20.199

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Graphical Abstract

Figure 1: Overall chemical proteomics strategy to identify protein targets of natural products (NPs) and simi...

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Figure 2: A) Design of mostly used photo-crosslinking groups. B) Mass spectrometry properties of proteins PTM...

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Figure 3: Direct and indirect approach to identify protein targets and representative chemical proteomics wor...

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Figure 4: Products of the CuAAC side reactions.

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Figure 5: Search possibilities on peptide-level characterization. A) Comparison of DDA and DIA techniques. B)...

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Figure 6: In-gel analysis using a tag with fluorophore (A) or via shift-assay (B).

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Figure 7: Reporter linkers. A) DMP-tag. B) AzidoTMT tag. C) SOX-tag. D) Imidazolium tag. *A star indicates th...

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Figure 8: Biotin and desthiobition-based sample linkers and their associated diagnostic peaks. A) Structure o...

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Figure 9: A) isoDTB linker and probe-specific diagnostic ions (B). *A star indicates the possible introductio...

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Figure 10: TEV-cleavable linker structure with its characteristic diagnostic ions (A) and probe-specific diagn...

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Figure 11: A) Structure of the full length DADPS linker and remaining part after cleavage. B) Diagnostic ions....

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Figure 12: Diagnostic peaks included in the search identify higher numbers of modified PSMs and peptides using...

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Figure 13: An alternative DADPS linker.

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Figure 14: Chemical structure of the trifunctional trypsin cleavable AzKTB linker.

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Review

Published 12 Sep 2024

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