Beilstein J. Org. Chem.2010,6, 1206–1210, doi:10.3762/bjoc.6.138
, diastereoselective sequence of two [3 + 2] cycloadditionreactions promoted by triflic acid where the large 1,3-diol protecting group – the 1,1,3,3-tetraisopropoxydisiloxanylidene group (TIPDS) – plays a crucial role in facial discrimination.
Results and Discussion
Our approach to the preparation of enantiomerically
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Graphical Abstract
Scheme 1:
Retrosynthetic analysis outlining the stereocontrolled construction of the aminopolyol core of (−)-...