Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine

• Manfred Braun and
• Torsten Dittrich

Beilstein J. Org. Chem. 2010, 6, No. 69, doi:10.3762/bjoc.6.69

• treatment with tert-butyl(dimethyl)silyl chloride gave alcohol 4 in 59% yield after removal of the doubly silylated side product the formation of which could not be completely avoided. By means of an Appel reaction [15], the alcohol 4 was converted into the bromide 5 in 79% yield. In the following key-step

Sordarin, an antifungal agent with a unique mode of action

• Huan Liang

Beilstein J. Org. Chem. 2008, 4, No. 31, doi:10.3762/bjoc.4.31

• reaction with lithium cyclohexyl(isopropyl)amide (LCIA) in 49% overall yield for the 4-step sequence. The elaboration of intermediate 27 entailed a protection-deprotection maneuver that prepared the molecule for an ultimate Appel reaction [28] as a way to install the iodo substituent. The second key