Synthesis and enzymatic evaluation of 2- and 4-aminothiazole- based inhibitors of neuronal nitric oxide synthase

• Graham R. Lawton,
• Haitao Ji,
• Pavel Martásek,
• Linda J. Roman and
• Richard B. Silverman

Beilstein J. Org. Chem. 2009, 5, No. 28, doi:10.3762/bjoc.5.28

• completion of the reaction and reprotecting the amine. The resulting esters (26a, R = H; 26b, R= Me; 26c, R = i-Pr) were hydrolyzed, and a Curtius rearrangement performed in tert-butanol gave the protected 4-aminothiazoles (7a-c) [18]. Unlike the case of the aminopyridine analogues [19], the aminothiazole