The reactions of 2-ethoxymethylidene-3-oxo esters and their analogues with 5-aminotetrazole as a way to novel azaheterocycles

• Marina V. Goryaeva,
• Yanina V. Burgart,
• Marina A. Ezhikova,
• Mikhail I. Kodess and
• Viktor I. Saloutin

Beilstein J. Org. Chem. 2015, 11, 385–391, doi:10.3762/bjoc.11.44

• ], antiviral [14], antimicrobial and antioxidant activity [15] have been found among them. The known tetrazolo[1,5-a]pyrimidines were synthesized by cyclocondensation of 5-AT with 1,3-dicarbonyl compounds or their derivatives [16]. Moreover, a convenient method for obtaining this heterocyclic skeleton is the

Inclusion of trans-resveratrol in methylated cyclodextrins: synthesis and solid-state structures

• Lee Trollope,
• Dyanne L. Cruickshank,
• Terence Noonan,
• Susan A. Bourne,
• Milena Sorrenti,
• Laura Catenacci and
• Mino R. Caira

Beilstein J. Org. Chem. 2014, 10, 3136–3151, doi:10.3762/bjoc.10.331

• -resveratrol (5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol; trans-3,5,4′-trihydroxystilbene, RSV) (1, Figure 1), is a triphenolic species which is known to have potent antioxidant activity and consequently a wide range of pharmacological activities [1][2]. In recent years the list of potential medicinal

Effect of cyclodextrin complexation on phenylpropanoids’ solubility and antioxidant activity

• Miriana Kfoury,
• David Landy,
• Lizette Auezova,
• Hélène Greige-Gerges and
• Sophie Fourmentin

Beilstein J. Org. Chem. 2014, 10, 2322–2331, doi:10.3762/bjoc.10.241

• ) and the solubilizing potential of CD was proposed. Molecular modeling was used to investigate the complementarities between host and guest. Finally, the antioxidant activity of encapsulated PPs was evaluated by scavenging of the stable DPPH radical. Keywords: antioxidant activity; complexation

• antioxidant activity and therefore are considered to have beneficial effects on human health [3][4]. PPs are also known to have antibacterial, antifungal and anti-inflammatory properties [5][6][7]. However, they have restricted applications as pharmaceutical products and food preservatives because they have

• presented in Figure 5. Isoeugenol (3), eugenol (4), p-coumaric acid (5), caffeic acid (6) and ferulic acid (7) presented higher antioxidant activity than trans-anethole (1) and estragole (2). It is well known that the antioxidant activity of phenolic compounds such as PPs depends mainly on the degree of

3-Pyridinols and 5-pyrimidinols: Tailor-made for use in synergistic radical-trapping co-antioxidant systems

• Luca Valgimigli,
• Daniele Bartolomei,
• Riccardo Amorati,
• Evan Haidasz,
• Jason J. Hanthorn,
• Susheel J. Nara,
• Johan Brinkhorst and
• Derek A. Pratt

Beilstein J. Org. Chem. 2013, 9, 2781–2792, doi:10.3762/bjoc.9.313

• ), 5.71 (s, 2H); 13C NMR (CDCl3) δ 13.2, 18.4, 107.4, 128.6, 145.7, 149.3, 155.3; HRMS (EI+) m/z: calcd for C12H15N3O, 217.1215; found, 217.1217. Autoxidation studies. The chain-breaking antioxidant activity of the title compounds was evaluated by monitoring the course of thermally initiated inhibited

Methylidynetrisphosphonates: Promising C₁ building block for the design of phosphate mimetics

• Vadim D. Romanenko and
• Valery P. Kukhar

Beilstein J. Org. Chem. 2013, 9, 991–1001, doi:10.3762/bjoc.9.114

• μM) [46]. The antioxidant activity of the compound ArC(PO3Et2)3 (Ar = 2,6-t-Bu2-4-MeC6H2) was studied in a model oxidation of oleic acid and with biological objects (liver homogenates of Wistar rats) [36]. Among polyphosphonic acids with a geminal arrangement of phosphonic groups efficient

Bioactive selaginellins from Selaginella tamariscina (Beauv.) Spring

• Chao Yang,
• Yutian Shao,
• Kang Li and
• Wujiong Xia

Beilstein J. Org. Chem. 2012, 8, 1884–1889, doi:10.3762/bjoc.8.217

• -formyl-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene]cyclohexa-2,5-dien-1-one. Compound 1, 2 and 3 exhibited appreciable cytotoxic activity against cultured HeLa cells (human cervical carcinoma cells), as well as significant antioxidant activity. Keywords: antioxidant

• structural feature motivated the study on their antioxidant activity. Accordingly, the antioxidant capacity of selaginellin O (1), selaginellin M (2) and selaginellin (3) were estimated with the widely used ABTS radical-scavenging assay and FRAP assay. In both assays, all the selaginellins tested displayed

• significant antioxidant activity, with more potent antioxidant capacity than the reference compound Trolox (Supporting Information File 1; Table S2). Likewise, the new compound, selaginellin O (1), exhibited the highest antioxidant activity, and a general increase in antioxidant activity was observed compared