Asymmetric reactions in continuous flow

• Xiao Yin Mak,
• Paola Laurino and
• Peter H. Seeberger

Beilstein J. Org. Chem. 2009, 5, No. 19, doi:10.3762/bjoc.5.19

• in continuous flow asymmetric reactions using immobilized catalyst systems. An asymmetric reaction that has been examined extensively in continuous flow using supported catalysts is the enantioselective addition of diethylzinc to benzaldehyde [23][24][25][26][27][28]. A fast, single pass continuous

• ketone was investigated in flow using polystyrene-supported cinchonine and cinchonidine 27 (Scheme 8) [33]. A fluid bed reactor was devised for this asymmetric reaction, which allowed for the polymer beads to move around freely. Solutions of the reagents were introduced into the bottom of the column bed

Enantioselective nucleophilic difluoromethylation of aromatic aldehydes with Me₃SiCF₂SO₂Ph and PhSO₂CF₂H reagents catalyzed by chiral quaternary ammonium salts

• Chuanfa Ni,
• Fang Wang and
• Jinbo Hu

Beilstein J. Org. Chem. 2008, 4, No. 21, doi:10.3762/bjoc.4.21

• [36] or asymmetric synthesis of α,β-epoxysulfones [37], they were not as effective as 4-trifluoromethylphenyl functionality in the current asymmetric reaction (Table 2, entries 13, 15 and 16). In the light of these results, we next examined the substrate scope of this enantioselective

Stereoselective α-fluoroamide and α-fluoro- γ-lactone synthesis by an asymmetric zwitterionic aza-Claisen rearrangement

• Kenny Tenza,
• Julian S. Northen,
• David O'Hagan and
• Alexandra M. Z. Slawin

Beilstein J. Org. Chem. 2005, 1, No. 13, doi:10.1186/1860-5397-1-13

• the zwitterionic aza-Claisen rearrangement product in good yield and demonstrated the chemical feasibility of the approach. For the asymmetric reaction, N-allyl-(S)-2-(methoxymethyl)pyrrolidine was treated with either 2-fluoropropionyl chloride or 2-fluorophenylacetic acid chloride under similar