3-Pyridinols and 5-pyrimidinols: Tailor-made for use in synergistic radical-trapping co-antioxidant systems

• Luca Valgimigli,
• Daniele Bartolomei,
• Riccardo Amorati,
• Evan Haidasz,
• Jason J. Hanthorn,
• Susheel J. Nara,
• Johan Brinkhorst and
• Derek A. Pratt

Beilstein J. Org. Chem. 2013, 9, 2781–2792, doi:10.3762/bjoc.9.313

• stronger O–H bonds than equivalently substituted phenols, but possess similar reactivities toward autoxidation chain-carrying peroxyl radicals. These attributes suggest that 3-pyridinols and 5-pyrimidinols will be particularly effectiveco-antioxidants when used in combination with more common, but less

• reactive, phenolic antioxidants such as 2,6-di-tert-butyl-4-methylphenol (BHT), which we demonstrate herein. The antioxidants function in a synergistic manner to inhibit autoxidation; taking advantage of the higher reactivity of the 3-pyridinols/5-pyrimidinols to trap peroxyl radicals and using the less

• phenolic antioxidants, but which are equally efficacious as the 3-pyridinol/5-pyrimidinol antioxidants alone at higher loadings. Keywords: antioxidants; autoxidation; free radical; phenols; 3-pyridinols; 5-pyrimidinols; Introduction Radical-trapping (chain-breaking) antioxidants are arguably the most

Damage of polyesters by the atmospheric free radical oxidant NO₃^•: a product study involving model systems

• Catrin Goeschen and
• Uta Wille

Beilstein J. Org. Chem. 2013, 9, 1907–1916, doi:10.3762/bjoc.9.225

• materials, the chemical mechanism of polymer degradation is by far not fully understood. It has generally been assumed that polymer degradation involves a radical-mediated autoxidation mechanism, which propagates through hydrogen abstraction by an intermediate peroxyl radical ROO•. Although this

• autoxidation mechanism was initially proposed only for a limited number of polymers that contain activated allylic hydrogen atoms (for example rubber materials) [1][2][3][4][5], it has been universally adapted as general mechanism for polymer degradation. However, recent comprehensive high-level theoretical

• studies by Coote et al. clearly revealed that polymers possessing only saturated alkyl chains, for example polyesters, will not propagate autoxidation, particularly because the ROO–H bond-dissociation energy (BDE) is usually less than the BDE for unactivated R–H bonds [6]. Polymer surface coatings, which

Metal-free aerobic oxidations mediated by N-hydroxyphthalimide. A concise review

• Lucio Melone and
• Carlo Punta

Beilstein J. Org. Chem. 2013, 9, 1296–1310, doi:10.3762/bjoc.9.146

• the O2-mediated selective oxidation of organic compounds and looking for environmentally safe alternatives to metal catalysis. Keywords: autoxidation; free-radicals; metal-free; molecular oxygen; N-hydroxyphthalimide; Introduction The development of efficient and cheap catalytic systems for the

• the beneficial impact of selective oxidation on industrial chemistry [2][3][4][5]. Nevertheless, classical autoxidation is usually very slow at low temperatures, and catalysis is required to activate O2. Transition-metal salts are particularly effective for this scope [6], but their use is often

• the role of classical radical initiators obtained by thermal decomposition, we will focus on some intriguing redox systems, including nitric oxides, laccase, quinones and aldehydes, which allow operation under very mild conditions, offering efficient alternative solutions to the classical autoxidation

NHC-catalysed highly selective aerobic oxidation of nonactivated aldehydes

• Lennart Möhlmann,
• Stefan Ludwig and
• Siegfried Blechert

Beilstein J. Org. Chem. 2013, 9, 602–607, doi:10.3762/bjoc.9.65

• led to a higher total conversion. We suppose that this is caused by the oxidation of the NHC, i.e., the consumption of the umpolung catalyst [23]. With this result in hand we focused on the aerobic autoxidation using only D as a precatalyst. An interesting conversion of aromatic aldehydes to acids

Some aspects of radical chemistry in the assembly of complex molecular architectures

• Béatrice Quiclet-Sire and
• Samir Z. Zard

Beilstein J. Org. Chem. 2013, 9, 557–576, doi:10.3762/bjoc.9.61

• the allylation procedure with the simplest vinyl epoxide to furnish derivative 148. It is interesting to note that the carbon–carbon bond formation takes place in ketoester xanthate 146 on the carbon bearing the least acidic hydrogens. Triethylborane, through its autoxidation, serves to initiate the