Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups

• Julien Rolland,
• Xacobe C. Cambeiro,
• Carles Rodríguez-Escrich and
• Miquel A. Pericàs

Beilstein J. Org. Chem. 2009, 5, No. 56, doi:10.3762/bjoc.5.56

• continuous flow enantioselective processes [52] are still scarce [22][53][54][55][56][57] in spite of the enormous potential of this methodology. Herein, we report the development of a continuous flow system for the preparation of enantioenriched diarylmethanols using triarylboroxins as the ultimate aryl

• 89% ee. Continuous flow system System set-up For the continuous flow experiments, a system similar to that previously described for the enantioselective ethylation of aldehydes [23] was used (Figure 3). The flow reactor consists of a vertically mounted, fritted and jacketed low-pressure

• of reagents for the generation of PhZnEt, the observed enantioselectivities were comparable to those recorded with the homogeneous catalyst 1. Thus, further improvement of the present continuous flow system could possibly be achieved with the use of alternative sources of the arylating species [33

Radical carbonylations using a continuous microflow system

• Takahide Fukuyama,
• Md. Taifur Rahman,
• Naoya Kamata and
• Ilhyong Ryu

Beilstein J. Org. Chem. 2009, 5, No. 34, doi:10.3762/bjoc.5.34

• pressurized carbon monoxide gas. Good to excellent yields of carbonylated products were obtained via radical formylation, carbonylative cyclization and three-component coupling reactions, using tributyltin hydride or TTMSS as a radical mediator. Keywords: continuous flow system; microreactor; radical

Asymmetric reactions in continuous flow

• Xiao Yin Mak,
• Paola Laurino and
• Peter H. Seeberger

Beilstein J. Org. Chem. 2009, 5, No. 19, doi:10.3762/bjoc.5.19

• advantage of a continuous flow system, the resolution of a mixture of the racemic acetyl-amino acid (DL-58) was carried out in tandem with a microextractor for the selective separation of the resulting chiral products (Scheme 17). The racemic substrate was introduced into the microreactor in a buffered