Kinetics and mechanism of vanadium catalysed asymmetric cyanohydrin synthesis in propylene carbonate

• Michael North and
• Marta Omedes-Pujol

Beilstein J. Org. Chem. 2010, 6, 1043–1055, doi:10.3762/bjoc.6.119

• effective catalysts for asymmetric cyanohydrin synthesis have been found to involve cooperative catalysis [7][8][9], in which the aldehyde is activated by an acidic group and the cyanide source is activated by a basic group. The acid and base catalysts can be present within a single catalyst unit, or can be