Carbamate derivatives and sesquiterpenoids from the South China Sea gorgonian Melitodes squamata

• Li-Si Huang,
• Fei He,
• Hui Huang,
• Xiao-Yong Zhang and
• Shu-Hua Qi

Beilstein J. Org. Chem. 2012, 8, 170–176, doi:10.3762/bjoc.8.18

• ), (−)-4α,10β-aromadendranediol (8), (+)-4β,10β-aromadendranediol (9) were obtained from the South China Sea gorgonian coral Melitodes squamata Nutting. Compounds 1, 2, 6, and 7 were new, and their structures were established by spectroscopic analyses. Compounds 6 and 7 contained a taurine group that was

• , diterpenoids, prostanoids, and steroids [1][2]. However, nitrogen-containing compounds were relatively few obtained from gorgonians. Gorgonian Melitodes squamata Nutting belonging to Melithaea family is a kind of pharmaceutical coral that has the efficacy of relieving cough, bleeding, and diarrhea, soothing

• Factory, Qindao, People’s Republic of China. Animal material The South China Sea gorgonian coral Melitodes squamata Nutting was collected in Sanya, Hainan province, China in July 2008 and identified by Prof. Huang H., the South China Sea Institute of Oceanology, Academia Sinica. A voucher specimen (No

Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes

• Jan-Christoph Kehr,
• Douglas Gatte Picchi and
• Elke Dittmann

Beilstein J. Org. Chem. 2011, 7, 1622–1635, doi:10.3762/bjoc.7.191

• contributors to coral reef ecosystems and extremely rich in bioactive secondary metabolites. The first pathway described was the biosynthesis of barbamide (7) (Figure 5), a chlorinated lipopeptide with potent molluscidal activity. The lipopeptide contains a unique trichloroleucyl starter unit that is

A racemic formal total synthesis of clavukerin A using gold(I)-catalyzed cycloisomerization of 3-methoxy-1,6-enynes as the key strategy

• Jae Youp Cheong and
• Young Ho Rhee

Beilstein J. Org. Chem. 2011, 7, 740–743, doi:10.3762/bjoc.7.84

• sesquiterpene natural products. It was first isolated in 1983, by the group of Kitawara, from the Okinawa soft coral Clavularia koellikeri. The structure of clavukerin A was established by CD spectra and X-ray diffraction [1]. The first total synthesis of clavukerin A was reported by Asaoka in 1991, which was