Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.

• Celso Almeida,
• Stefan Kehraus,
• Miguel Prudêncio and
• Gabriele M. König

Beilstein J. Org. Chem. 2011, 7, 1636–1642, doi:10.3762/bjoc.7.192

• , papain, porcine cease and acetylcholine esterase) were performed according to Neumann et al. [19]. Compounds were tested for protein kinase inhibition assays (DYRK1A and CDK5) according to Bettayeb et al. [20]. The triglyceride accumulation inhibition in the 3T3-L1 murine adipocytes assay was performed

Oxidative allylic rearrangement of cycloalkenols: Formal total synthesis of enantiomerically pure trisporic acid B

• Silke Dubberke,
• Muhammad Abbas and
• Bernhard Westermann

Beilstein J. Org. Chem. 2011, 7, 421–425, doi:10.3762/bjoc.7.54

• resolution; natural products; oxidative rearrangement; pig liver esterase (PLE); trisporic acid B; Introduction The generation of chiral, non-racemic compounds bearing a stereogenic quaternary carbon centre is of great interest [1][2][3][4][5][6][7][8]. Therefore, much effort has been directed towards the

• synthesis of this stereogenic unit and solutions have been found, e.g., by Christoffers and d’Angelo [9][10][11]. We have already disclosed our results to obtain these products highly enantiomerically enriched by pig liver esterase (PLE) catalyzed saponification of α-substituted β-ketoesters [12][13]. We

• -ketoester 1c, the racemate 1c is resolved by a pig liver esterase (PLE)-catalyzed saponification reaction. As in other cases reported earlier, the racemic β-ketoesters are hydrolyzed with high stereoselectivity allowing the isolation of optically pure esters (–)-1. The corresponding hydrolysis products, the

(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties

• José L. Jiménez Blanco,
• Fernando Ortega-Caballero,
• Carmen Ortiz Mellet and
• José M. García Fernández

Beilstein J. Org. Chem. 2010, 6, No. 20, doi:10.3762/bjoc.6.20

• juvenile esterase gene as the target. The results showed that binding of a 20-mer DNG/DNA hexameric (ATATAT) chimera containing guanidinium linkages is more than 105.7 times stronger than the binding of the corresponding 20-mer of DNA. The hexameric DNG binds to DNA in a 1:1 ratio and is able to