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Search for "glycosidases" in Full Text gives 27 result(s) in Beilstein Journal of Organic Chemistry.

Synthesis and glycosidase inhibitory activity of new hexa- substituted C8-glycomimetics

  • Olivia Andriuzzi,
  • Christine Gravier-Pelletier,
  • Gildas Bertho,
  • Thierry Prangé and
  • Yves Le Merrer

Beilstein J. Org. Chem. 2005, 1, No. 12, doi:10.1186/1860-5397-1-12

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  • , Laboratoire de Cristallographie et RMN Biologiques, 4 avenue de l'Observatoire, 75270 Paris Cedex 06, France 10.1186/1860-5397-1-12 Abstract Background Glycosidases are involved in several metabolic pathways and the development of inhibitors is an important challenge towards the treatment of diseases, such
  • particular case, due to the hindered conformation of such epoxides as demonstrated by X-ray cristallographic analysis. Conclusion The biological activity of the synthesized glycomimetics has been evaluated towards 24 commercially available glycosidases. The weak observed activities can probably be related to
  • towards glycosidases, while the core structure and essential network of hydroxyl functionalities for enzyme recognition are retained. An important example is the 1-deoxynojirimycin (DNJ) family, for which DNJ itself is a competitive inhibitor of α-D-glucosidase (Ki = 8–25 μM),[10] while its derivatives
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Published 07 Oct 2005
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  • LS2 9JT, UK School of Chemistry, University of Leeds, Leeds LS2 9JT, UK 10.1186/1860-5397-1-2 Abstract Background Many polyhydroxylated piperidines are inhibitors of the oligosaccharide processing enzymes, glycosidases and glycosyltransferases. Aza-C-linked disaccharide mimetics are compounds in
  • polyhydroxylated piperidines are potent inhibitors of the oligosaccharide processing enzymes, glycosidases and glycosyltransferases.[1][2][3] For example, deoxymannojirimycin, 1, and deoxynojirimycin, 2, are selective mannosidase and glucosidase inhibitors respectively.[4][5] In these molecules, the nitrogen atom
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Published 26 Aug 2005
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