Microwave- assisted ring closure reactions: Synthesis of 8-substituted xanthine derivatives and related pyrimido- and diazepinopurinediones

• Joachim C. Burbiel,
• Jörg Hockemeyer and
• Christa E. Müller

Beilstein J. Org. Chem. 2006, 2, No. 20, doi:10.1186/1860-5397-2-20

• poor mixing. Microwave-assisted synthesis has been extensively applied in the field of heterocyclic chemistry, especially when high temperatures are needed for ring formation with conventional heating [24]. Based on these findings the preparation of 8-substituted xanthine derivatives and related