Beilstein J. Org. Chem.2010,6, No. 21, doi:10.3762/bjoc.6.21
substituents of the new N-modified 1-galactonojirimycin derivatives on their biological interaction with respective glycoside hydrolases are described.
Results and Discussion
The key intermediate for the synthesis of N-modified lipophilic 1-deoxygalactonojirimycin derivatives 16–20 as well as 22 was the 3,4-O
Beilstein J. Org. Chem.2009,5, No. 10, doi:10.3762/bjoc.5.10
(triacyl glycerol hydrolases EC 3.1.1.3) catalyze hydrolysis, esterification, transesterification, thioesterification, amidation, epoxidation etc. [5][6][7][8][9][10]. The use of immobilized lipases is on the rise, as these work well with non-aqueous media [11]. Apart from the convenient handling, these