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Search for "liquid-assisted grinding" in Full Text gives 30 result(s) in Beilstein Journal of Organic Chemistry.
Mechanochemistry-assisted synthesis of hierarchical porous carbons applied as supercapacitors
Beilstein J. Org. Chem. 2017, 13, 1332–1341, doi:10.3762/bjoc.13.130
- of 0.20 cm3 g−1 and a surface area of 291 m2 g−1. Indeed, the high temperature chlorination reaction is essential to obtain the full porosity of the desired carbon. However, when we conducted the mechanochemical polymerization in the presence of small amounts of ethanol (liquid-assisted grinding, LA
Nucleophilic displacement reactions of 5′-derivatised nucleosides in a vibration ball mill
Beilstein J. Org. Chem. 2017, 13, 87–92, doi:10.3762/bjoc.13.11
- ′-tosylates in five to 60 minutes. Under these conditions, commonly-encountered nucleoside cyclisation byproducts (especially of purine nucleosides) were not observed. Liquid-assisted grinding of the same 5'-iodide and 5′-tosylate substrates with potassium selenocyanate in the presence of DMF produced the
- from nucleosides by 4-methoxybenzylthiolate using vibration ball milling (VBM) where competing intramolecular cyclisation reactions are completely avoided. We further demonstrate the application of liquid-assisted grinding to related displacements using potassium selenocyanate. Results and Discussion
- ) remained untransformed during (dry) VBM or liquid-assisted grinding (LAG) in the presence of DMF with excess KSeCN (3 equiv). As found previously, the addition of catalytic TBAI (vide supra) did not alter this outcome nor did the use of a larger excess (5 equiv) of selenocyanate. The addition of DMF to the
Extrusion – back to the future: Using an established technique to reform automated chemical synthesis
Beilstein J. Org. Chem. 2017, 13, 65–75, doi:10.3762/bjoc.13.9
- formation In 2009, Alvarez-Nunez et al. of Amgen used TSE to scale up the synthesis of a cocrystal which had already been reported to be synthesised successfully by ball milling (employing liquid-assisted grinding (LAG)). This was the first example demonstrating that mechanochemical synthesis could be
- amounts of solvent can be added to accelerate reactions (liquid-assisted grinding). Therefore, it can be concluded that the extruder provides most, if not all of the parameters that conventional solvent-based synthesis can provide. In fact, in regards to the current drive towards a more sustainable
Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins
Beilstein J. Org. Chem. 2017, 13, 19–25, doi:10.3762/bjoc.13.3
- investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding
- agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures. Keywords: ball-milling; 1,1’-carbonyldiimidazole (CDI); hydantoins; mechanochemistry; liquid-assisted grinding (LAG); poly(ethylene) glycols (PEGs); Introduction Poly(ethylene
- (0.119 cSt) led to comparable yields when replaced by a more viscous liquid like glycerol (1.12 cSt) (Table 1, entry 14), an eco-friendly solvent still not investigated for liquid-assisted grinding procedures. In fact such a compound is becoming a green source of several building blocks since glycerol is
Mechanochemistry assisted asymmetric organocatalysis: A sustainable approach
Beilstein J. Org. Chem. 2012, 8, 2132–2141, doi:10.3762/bjoc.8.240
- grinding and liquid-assisted grinding (LAG) have been applied to the synthesis of mono- and bis(thiourea)s in quantitative yield by using the click coupling of aromatic or aliphatic diamines with aromatic isothiocyanates (Scheme 9) [54]. The mechanochemically prepared chiral molecules were applied as
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