Chiral phosphines in nucleophilic organocatalysis

• Yumei Xiao,
• Zhanhu Sun,
• Hongchao Guo and
• Ohyun Kwon

Beilstein J. Org. Chem. 2014, 10, 2089–2121, doi:10.3762/bjoc.10.218

• the optimal catalyst. Based on the X-ray crystal structure of the catalyst, they proposed that the chiral microenvironment of the binaphthyl-based phosphepine was amplified by its 3,3´-diphenyl substituents. In the presence of the chiral phosphepine B4, the reactions of allenes with electron-deficient

Pyrene-modified PNAs: Stacking interactions and selective excimer emission in PNA₂DNA triplexes

• Alex Manicardi,
• Lucia Guidi,
• Alice Ghidini and
• Roberto Corradini

Beilstein J. Org. Chem. 2014, 10, 1495–1503, doi:10.3762/bjoc.10.154

• [9][10]. Among the possible reporter groups, pyrene has been proposed in several in vitro detection systems, due to the sensitivity of its fluorescence properties to microenvironment and due to its ability to produce stabilizing stacking interactions and to show excimer fluorescence [11][12][13][14

Design of a novel tryptophan-rich membrane-active antimicrobial peptide from the membrane-proximal region of the HIV glycoprotein, gp41

• Evan F. Haney,
• Leonard T. Nguyen,
• David J. Schibli and
• Hans J. Vogel

Beilstein J. Org. Chem. 2012, 8, 1172–1184, doi:10.3762/bjoc.8.130

• concentration was substantially higher than the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values (Table 1). Tryptophan fluorescence spectroscopy Tryptophan emission fluorescence of all the gp41w derivatives was performed to examine the microenvironment surrounding the

An easily accessible sulfated saccharide mimetic inhibits in vitro human tumor cell adhesion and angiogenesis of vascular endothelial cells

• Grazia Marano,
• Claas Gronewold,
• Martin Frank,
• Anette Merling,
• Christian Kliem,
• Sandra Sauer,
• Manfred Wiessler,
• Eva Frei and
• Reinhard Schwartz-Albiez

Beilstein J. Org. Chem. 2012, 8, 787–803, doi:10.3762/bjoc.8.89

• microenvironment resulting in an increased malignancy. Schmidt’s imidate strategy offers an effective method to synthesize libraries of various oligosaccharide mimetics. With the aim to perturb interactions of tumor cells with extracellular matrix proteins and host cells, molecules with 3,4-bis(hydroxymethyl)furan

• cellular processes, such as adhesion to the ECM, and modulation of the tumor-associated microenvironment, which represent advantages for the capacity of the cell to invade the host tissue and to secure undisturbed growth [7]. The glycosylation pattern of tumor cells is therefore the focus in the

Molecular recognition of organic ammonium ions in solution using synthetic receptors

• Andreas Späth and
• Burkhard König

Beilstein J. Org. Chem. 2010, 6, No. 32, doi:10.3762/bjoc.6.32