Convenient preparation of high molecular weight poly(dimethylsiloxane) using thermally latent NHC-catalysis: a structure-activity correlation

• Stefan Naumann,
• Johannes Klein,
• Dongren Wang and
• Michael R. Buchmeiser

Beilstein J. Org. Chem. 2015, 11, 2261–2266, doi:10.3762/bjoc.11.246

• in situ from thermally labile CO2 adducts. This type of NHC delivery offers the double advantage of improved stability and storability of the NHC adduct and the possibility to generate “on demand” polymerization systems where the catalyst can be activated by heating. This way, a latent, easy-to

• thermally labile pre-catalysts both practically feasible and advantageous. Conclusion In conclusion, we have demonstrated the first polymerization of D4 using NHC-carboxylates. Sterically non-hindered, highly nucleophilic protected NHCs like 5Me-Me-CO2 offer access to an “on demand”, metal-free and

Asymmetric 1,4-bis(ethynyl)bicyclo[2.2.2]octane rotators via monocarbinol functionalization. Ready access to polyrotors

• Cyprien Lemouchi and
• Patrick Batail

Beilstein J. Org. Chem. 2015, 11, 1881–1885, doi:10.3762/bjoc.11.202

• dirotors in higher yield than our former [10][12] synthesis of 6 and with very diverse functional groups (Scheme 2). Hence, large quantities of the diyne diester dirotor, 9 are obtained (Scheme 2) providing ready, on-demand access to 10. The dirotors 3, 6 and 9 are synthesized by palladium-catalyzed

Ruthenium indenylidene “1^st generation” olefin metathesis catalysts containing triisopropyl phosphite

• Stefano Guidone,
• Fady Nahra,
• Alexandra M. Z. Slawin and
• Catherine S. J. Cazin

Beilstein J. Org. Chem. 2015, 11, 1520–1527, doi:10.3762/bjoc.11.166

• polymerization on demand through use of a stimulus [35][36]. The use of this catalyst in the ring-closing metathesis (RCM) reaction gave excellent conversions of challenging substrates, even at low catalyst loadings. The high activity and robustness of cis-Caz-1 is derived from synergistic effects between the σ

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

• Marcus Baumann and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2015, 11, 1194–1219, doi:10.3762/bjoc.11.134

• reactor. This enables the quick and easy relocation of manufacturing to permit medications to be made bespoke at the site of requirement or in future applications on demand as required by the patient or prescriber. It is also worth highlighting here two European initiatives in this regrad, namely CoPIRIDE

Photoswitchable precision glycooligomers and their lectin binding

• Daniela Ponader,
• Sinaida Igde,
• Marko Wehle,
• Katharina Märker,
• Mark Santer,
• David Bléger and
• Laura Hartmann

Beilstein J. Org. Chem. 2014, 10, 1603–1612, doi:10.3762/bjoc.10.166

• affinity towards PA-IL lectins on demand, we were intrigued in the ability of our light-responsive systems to work when immobilized on a surface. To this end we attached the photoswitchable precision glycooligomers directly to the SPR chip and performed a second set of lectin binding experiments using SPR

Flow microreactor synthesis in organo-fluorine chemistry

• Hideki Amii,
• Aiichiro Nagaki and
• Jun-ichi Yoshida

Beilstein J. Org. Chem. 2013, 9, 2793–2802, doi:10.3762/bjoc.9.314

• , [18F]FDG is radiopharmaceutically used for positron emission tomography (PET). However, due to the short radioactivity elimination half-life of [18F] (t1/2 = 110 min), protocols for rapid and selective synthesis of [18F]-labeled compounds have been required. In addition, on-site and on-demand chemical

Ethyl diazoacetate synthesis in flow

• Mariëlle M. E. Delville,
• Jan C. M. van Hest and
• Floris P. J. T. Rutjes

Beilstein J. Org. Chem. 2013, 9, 1813–1818, doi:10.3762/bjoc.9.211

• used on lab scale. Its highly explosive nature, however, severely limits its use in industrial processes. The in-line coupling of microreactor synthesis and separation technology enables the synthesis of this compound in an inherently safe manner, thereby making it available on demand in sufficient

The rapid generation of isothiocyanates in flow

• Marcus Baumann and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2013, 9, 1613–1619, doi:10.3762/bjoc.9.184

• synthesis is playing an increasingly pivotal role within the chemical sciences as it facilitates a more versatile and responsive workflow. It encompasses many aspects of synthesis from the rapid and on-demand preparation of important building blocks to the development of multi-step sequences leading to

Synthesis and testing of the first azobenzene mannobioside as photoswitchable ligand for the bacterial lectin FimH

• Vijayanand Chandrasekaran,
• Katharina Kolbe,
• Femke Beiroth and
• Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2013, 9, 223–233, doi:10.3762/bjoc.9.26

• powerful antagonists is highly desirable, however, ideally on demand, that is, in a specific and spatially as well as temporally resolved way. Often bacterial adhesion depends on the interaction of adhesive organelles called fimbriae. They project from the surface of bacteria and contain lectin domains to

Hybrid biofunctional nanostructures as stimuli-responsive catalytic systems

• Gernot U. Marten,
• Thorsten Gelbrich and
• Annette M. Schmidt

Beilstein J. Org. Chem. 2010, 6, 922–931, doi:10.3762/bjoc.6.98

• nanoparticles; immobilization matrix; thermoflocculation; Introduction The use of an external stimulus for the activation of (bio)chemical reaction processes can be a valuable tool in fundamental research and in applications such as reaction kits or lab-on-a-chip systems, as it allows for on-demand triggering

Asymmetric reactions in continuous flow

• Xiao Yin Mak,
• Paola Laurino and
• Peter H. Seeberger

Beilstein J. Org. Chem. 2009, 5, No. 19, doi:10.3762/bjoc.5.19

• reproducibility due to the precise control over reaction conditions in these devices. Continuous flow technology has excellent potential for the integration of a high level of automation and for the incorporation of on-demand reaction analysis. This can be advantageous for applications such as high-throughput