Photoswitchable precision glycooligomers and their lectin binding

• Daniela Ponader,
• Sinaida Igde,
• Marko Wehle,
• Katharina Märker,
• Mark Santer,
• David Bléger and
• Laura Hartmann

Beilstein J. Org. Chem. 2014, 10, 1603–1612, doi:10.3762/bjoc.10.166

• affinity towards PA-IL lectins on demand, we were intrigued in the ability of our light-responsive systems to work when immobilized on a surface. To this end we attached the photoswitchable precision glycooligomers directly to the SPR chip and performed a second set of lectin binding experiments using SPR

Flow microreactor synthesis in organo-fluorine chemistry

• Hideki Amii,
• Aiichiro Nagaki and
• Jun-ichi Yoshida

Beilstein J. Org. Chem. 2013, 9, 2793–2802, doi:10.3762/bjoc.9.314

• , [18F]FDG is radiopharmaceutically used for positron emission tomography (PET). However, due to the short radioactivity elimination half-life of [18F] (t1/2 = 110 min), protocols for rapid and selective synthesis of [18F]-labeled compounds have been required. In addition, on-site and on-demand chemical

Ethyl diazoacetate synthesis in flow

• Mariëlle M. E. Delville,
• Jan C. M. van Hest and
• Floris P. J. T. Rutjes

Beilstein J. Org. Chem. 2013, 9, 1813–1818, doi:10.3762/bjoc.9.211

• used on lab scale. Its highly explosive nature, however, severely limits its use in industrial processes. The in-line coupling of microreactor synthesis and separation technology enables the synthesis of this compound in an inherently safe manner, thereby making it available on demand in sufficient

The rapid generation of isothiocyanates in flow

• Marcus Baumann and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2013, 9, 1613–1619, doi:10.3762/bjoc.9.184

• synthesis is playing an increasingly pivotal role within the chemical sciences as it facilitates a more versatile and responsive workflow. It encompasses many aspects of synthesis from the rapid and on-demand preparation of important building blocks to the development of multi-step sequences leading to

Synthesis and testing of the first azobenzene mannobioside as photoswitchable ligand for the bacterial lectin FimH

• Vijayanand Chandrasekaran,
• Katharina Kolbe,
• Femke Beiroth and
• Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2013, 9, 223–233, doi:10.3762/bjoc.9.26

• powerful antagonists is highly desirable, however, ideally on demand, that is, in a specific and spatially as well as temporally resolved way. Often bacterial adhesion depends on the interaction of adhesive organelles called fimbriae. They project from the surface of bacteria and contain lectin domains to

Hybrid biofunctional nanostructures as stimuli-responsive catalytic systems

• Gernot U. Marten,
• Thorsten Gelbrich and
• Annette M. Schmidt

Beilstein J. Org. Chem. 2010, 6, 922–931, doi:10.3762/bjoc.6.98

• nanoparticles; immobilization matrix; thermoflocculation; Introduction The use of an external stimulus for the activation of (bio)chemical reaction processes can be a valuable tool in fundamental research and in applications such as reaction kits or lab-on-a-chip systems, as it allows for on-demand triggering

Asymmetric reactions in continuous flow

• Xiao Yin Mak,
• Paola Laurino and
• Peter H. Seeberger

Beilstein J. Org. Chem. 2009, 5, No. 19, doi:10.3762/bjoc.5.19

• reproducibility due to the precise control over reaction conditions in these devices. Continuous flow technology has excellent potential for the integration of a high level of automation and for the incorporation of on-demand reaction analysis. This can be advantageous for applications such as high-throughput