Metal and metal-free photocatalysts: mechanistic approach and application as photoinitiators of photopolymerization

• Jacques Lalevée,
• Sofia Telitel,
• Pu Xiao,
• Marc Lepeltier,
• Frédéric Dumur,
• Fabrice Morlet-Savary,
• Didier Gigmes and
• Jean-Pierre Fouassier

Beilstein J. Org. Chem. 2014, 10, 863–876, doi:10.3762/bjoc.10.83

• organometallic complexes are mostly employed as radical sources: they exhibit an excellent visible-light absorption, long lived excited states and suitable redox potentials and they work through either an oxidation or a reduction cycle [1][2][3][4][5][6][7][8][9][10][11][12]. To avoid, however, the high cost

True and masked three-coordinate T-shaped platinum(II) intermediates

• Manuel A. Ortuño,
• Salvador Conejero and
• Agustí Lledós

Beilstein J. Org. Chem. 2013, 9, 1352–1382, doi:10.3762/bjoc.9.153

• been invoked as crucial intermediates in reactions involving late transition-metal complexes. Ligand dissociation, forming intermediates with open coordination sites, has been proposed as the initial step in many reactions involving square-planar d8 organometallic complexes [1]. Four-coordinate square

Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery

• Jan Hoyer,
• Ulrich Schatzschneider,
• Michaela Schulz-Siegmund and
• Ines Neundorf

Beilstein J. Org. Chem. 2012, 8, 1788–1797, doi:10.3762/bjoc.8.204

• (cymantrene) complexes to tumor cell lines, inducing high cellular toxicity. In order to increase the potential of the organometallic complexes to kill tumor cells, we were looking for a way to enhance cellular uptake. Therefore, we designed a branched dimeric variant of sC18, (sC18)2, which was shown to have

• a cell-penetrating peptide. Keywords: anti-tumor agents; cell-penetrating peptides; drug delivery; internalization studies; organometallic complexes; peptides; Introduction A substantial problem concerning promising drug candidates is often their incapacity to reach their full therapeutic

• pronounced after introduction of an enzymatic cleavage site [12]. However, the aim of the present study was to investigate whether the cytotoxic effect of these organometallic complexes can be further increased by conjugating them to a dimeric variant of sC18, (sC18)2, since previous studies demonstrated

Meta-metallation of N,N-dimethylaniline: Contrasting direct sodium-mediated zincation with indirect sodiation-dialkylzinc co-complexation

• David R. Armstrong,
• Liam Balloch,
• Eva Hevia,
• Alan R. Kennedy,
• Robert E. Mulvey,
• Charles T. O'Hara and
• Stuart D. Robertson

Beilstein J. Org. Chem. 2011, 7, 1234–1248, doi:10.3762/bjoc.7.144

• -complexation approaches. The results of this study highlight the inherent complexity of these metallation reactions even at the metal stage, with a diverse array of organometallic complexes isolated, prior to the recognised intricacies of subsequent electrophilic interception. Collectively, these results

Stereoselectivity of supported alkene metathesis catalysts: a goal and a tool to characterize active sites

• Christophe Copéret

Beilstein J. Org. Chem. 2011, 7, 13–21, doi:10.3762/bjoc.7.3

• –inorganic materials [43], where surface functionalities such as typical organic ligands are perfectly distributed within the pore networks of a mesoporous silica. For other approaches used to prepare supported homogeneous catalysts, see the reviews [44][45][46]. Selective grafting of organometallic

• complexes onto these pendant ligands can then be performed. Using this technology, several materials containing N-heterocyclic metal units (M–NHC) have been prepared, including a system containing a Ru–NHC unit (Scheme 5), which displayed unprecedented activity in the metathesis of ethyl oleate with