Shelf-stable electrophilic trifluoromethylating reagents: A brief historical perspective

• Norio Shibata,
• Andrej Matsnev and
• Dominique Cahard

Beilstein J. Org. Chem. 2010, 6, No. 65, doi:10.3762/bjoc.6.65

• -nitro esters. In particular, reagent 37 was found to be an effective trifluoromethylating agent. Under phase-transfer catalysis the β-keto esters derived from indanone, tetralone and pentanone in the presence of 37 gave the corresponding trifluoromethylated product in 42–67% yields. The new reagents

Templated versus non-templated synthesis of benzo-21-crown-7 and the influence of substituents on its complexing properties

• Wei Jiang and
• Christoph A. Schalley

Beilstein J. Org. Chem. 2010, 6, No. 14, doi:10.3762/bjoc.6.14

• intramolecular ring closure in the absence of phase-transfer catalysis, we synthesized the monotosylate 1 which is then used in a separate macrocyclization (Scheme 1). Disappointingly, only 24% yield was achieved for the synthesis of C7 from 1. A second fraction of 31% turned out to be a mixture of C7’s bigger