New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei

• Annamaria Sinisi,
• Barbara Calcinai,
• Carlo Cerrano,
• Henny A. Dien,
• Angela Zampella,
• Claudio D’Amore,
• Barbara Renga,
• Stefano Fiorucci and
• Orazio Taglialatela-Scafati

Beilstein J. Org. Chem. 2013, 9, 1643–1651, doi:10.3762/bjoc.9.188

• reference compound in the class of actin interacting cell growth inhibitors [5]), polyene derivatives (as aurantosides [6]), and polypeptides/depsipeptides. The biosynthesis of several secondary metabolites of Theonella has been ascribed to symbiotic microorganisms, as in the case of the polyketide onnamide

• [7] and the polypeptide polytheonamide [8]. It is, however, not unreasonable to presume that a symbiotic role in the production of secondary metabolites could be crucial in many other cases. Probably the most distinctive class of secondary metabolites of Theonella is given by complex polypeptides

• whose uncommon amino acids have been postulated to have either nonribosomal (NR) or post-translationally modified ribosomal (PMR) origin [8]. Several classes of Theonella polypeptides have been isolated to date, and they often show peculiar features such as largely rearranged amino acidic units, either

Design of a novel tryptophan-rich membrane-active antimicrobial peptide from the membrane-proximal region of the HIV glycoprotein, gp41

• Evan F. Haney,
• Leonard T. Nguyen,
• David J. Schibli and
• Hans J. Vogel

Beilstein J. Org. Chem. 2012, 8, 1172–1184, doi:10.3762/bjoc.8.130

• extremely hemolytic. This work demonstrates a novel approach for the design of unexplored antimicrobial peptide sequences but it also reveals that the biological and cytotoxic activities of these polypeptides depend on a number of interrelated factors. Keywords: antimicrobial peptides; cytotoxic peptides

• , ranging from diverse peptides isolated from different natural sources to synthetic peptides generated with high-throughput screening methods. From this large sample size, a number of characteristics have been identified that all contribute to the antimicrobial potency of these polypeptides. In this study

Synthetic glycopeptides and glycoproteins with applications in biological research

• Ulrika Westerlind

Beilstein J. Org. Chem. 2012, 8, 804–818, doi:10.3762/bjoc.8.90

• tandem repeat polypeptides have been prepared, and such polypeptides are useful for the development of anti-tumor vaccines [49][50]. The bovine ribonuclease C glycoprotein (RNase C) has been used as a model system for the preparation of homogenous N-glycoproteins, employing NCL and EPL for coupling

Pyridinium based amphiphilic hydrogelators as potential antibacterial agents

• Sayanti Brahmachari,
• Sisir Debnath,
• Sounak Dutta and
• Prasanta Kumar Das

Beilstein J. Org. Chem. 2010, 6, 859–868, doi:10.3762/bjoc.6.101

• origin [18] (poly(acrylic acid) and derivatives, polypeptides and small molecules). This fascinating class of materials results from the spontaneous self-assembly of polymeric/non-polymeric molecules that lead to the formation of supramolecular three dimensional (3D) networks with interstitial space for

(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties

• José L. Jiménez Blanco,
• Fernando Ortega-Caballero,
• Carmen Ortiz Mellet and
• José M. García Fernández

Beilstein J. Org. Chem. 2010, 6, No. 20, doi:10.3762/bjoc.6.20

• units present, more so than is the case with other biomolecules such as polypeptides or oligonucleotides. This is determined by the stereochemical identity of the monosaccharide units present (e.g. glucose, galactose, mannose), their glycosidic linkage positions (e.g. 1→4, 1→6), the nature at anomeric