Microwave assisted synthesis of triazoloquinazolinones and benzimidazoquinazolinones

• Aboul-Fetouh E. Mourad,
• Ashraf A. Aly,
• Hassan H. Farag and
• Eman A. Beshr

Beilstein J. Org. Chem. 2007, 3, No. 11, doi:10.1186/1860-5397-3-11

• -Minia University, 61519-El-Minia, Egypt 10.1186/1860-5397-3-11 Abstract Background Benzimidazoquinazolinones and related quinazolines are classes of heterocycles that are of considerable interest because of the diverse range of their biological properties. Although numerous classes of quinazolines have

• compounds with 2-ethoxymethyleneaminonitriles. [9] A general route to prepare 5,10-dihydro-[1,2,4]-triazolo-[5,1-b]-quinazolines included the reaction of benzophenone and 1-ureidoethylidene-hydrazones with a mixture of triphenylphosphine, carbon tetrachloride, and triethylamine in dichloromethane. [10

• ] Other triazoloquinazolines were obtained from 2'-azidoacetophenone and as well as 2-azidobenzonitrile. [11] Quinazolines were also obtained in moderate yields by an intermolecular reductive N-heterocyclization of 2-nitro-benzaldehydes or 2-nitrophenyl ketones with formamide catalyzed by a combination of