Tanzawaic acids I–L: Four new polyketides from Penicillium sp. IBWF104-06

• Louis P. Sandjo,
• Eckhard Thines,
• Till Opatz and
• Anja Schüffler

Beilstein J. Org. Chem. 2014, 10, 251–258, doi:10.3762/bjoc.10.20

• secondary metabolism of fungal species for the identification of novel lead structures for agrochemical and pharmaceutical research, we isolated a fungal strain from a soil sample. The culture filtrate extract of this organism was found to inhibit the conidial germination in the rice blast fungus

Novel fatty acid methyl esters from the actinomycete Micromonospora aurantiaca

• Jeroen S. Dickschat,
• Hilke Bruns and
• Ramona Riclea

Beilstein J. Org. Chem. 2011, 7, 1697–1712, doi:10.3762/bjoc.7.200

• methylmalonyl-CoA was determined by feeding experiments [14]. During our ongoing analysis of the volatiles released by different bacteria and fungi with high potential for secondary metabolism, the actinomycete Micromonospora aurantiaca ATCC 27029 came to our attention. This gram-positive, sporulating bacterial

Tertiary alcohol preferred: Hydroxylation of trans-3-methyl-L-proline with proline hydroxylases

• Christian Klein and
• Wolfgang Hüttel

Beilstein J. Org. Chem. 2011, 7, 1643–1647, doi:10.3762/bjoc.7.193

• , proline hydroxylases exclusively hydroxylate the free L-amino acid and are limited to some bacteria and filamentous fungi. As far as it is known, they are involved in secondary metabolism, for example, in the biosynthesis of the non-ribosomal peptide antibiotics etamycin, telomycin and pneumocandin [22

• ability of non-heme iron(II) enzymes to oxidize tertiary carbon centers. To our knowledge, the formation of tertiary alcohols with α-ketoglutarate (α-KG) dependent iron(II) oxygenases has not been previously reported. These enzymes typically catalyze CH-activation reactions in primary and secondary

• metabolism [17][18][19][20][21]. For the catalytic cycle, one α-KG and one oxygen molecule are required, besides the main substrate. The ketoacid is decarboxylated oxidatively by one oxygen atom from O2, whereas the other is used for substrate oxidation (Scheme 1). Here, we describe a regio- and

Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.

• Celso Almeida,
• Stefan Kehraus,
• Miguel Prudêncio and
• Gabriele M. König

Beilstein J. Org. Chem. 2011, 7, 1636–1642, doi:10.3762/bjoc.7.192

• (4). The skeleton of marilones A and B is most unusual, and its biosynthesis is suggested to require unique biochemical reactions considering fungal secondary metabolism. Marilone A (1) was found to have antiplasmodial activity against Plasmodium berghei liver stages with an IC50 of 12.1 µM. Marilone

• structural skeleton of marilones A and B is most unusual, and its biosynthesis is suggested to require unique reactions in fungal secondary metabolism. Marilone A (1) exhibited antiplasmodial activity against Plasmodium berghei with an IC50 of 12.1 µM. Marilone B (2) showed a specific antagonistic effect on