Amines as key building blocks in Pd-assisted multicomponent processes

• Didier Bouyssi,
• Nuno Monteiro and
• Geneviève Balme

Beilstein J. Org. Chem. 2011, 7, 1387–1406, doi:10.3762/bjoc.7.163

• α-arylation product, followed by iminium formation in the presence of a secondary amine and subsequent tandem cyclization. The authors showed the importance of the ratio of the diverse reactants, notably that the amount of amine should remain low to avoid formation of aminal derivatives that would

Recent developments in gold-catalyzed cycloaddition reactions

• Fernando López and
• José L. Mascareñas

Beilstein J. Org. Chem. 2011, 7, 1075–1094, doi:10.3762/bjoc.7.124

• authors proposed that these intermediates formally behave as an all-carbon 1,4-dipole that intermolecularly reacts with the indole providing the final polycyclic furan adducts 9 in a regioselective fashion (Scheme 4) [46]. In 2009, J. Zhang reported a gold(I)-catalyzed tandem cyclization/(3 + 3

Recent advances in the gold-catalyzed additions to C–C multiple bonds

• He Huang,
• Yu Zhou and
• Hong Liu

Beilstein J. Org. Chem. 2011, 7, 897–936, doi:10.3762/bjoc.7.103

• intramolecular hydroalkoxylation was reported by Zhang and co-workers [30]. A tandem cyclization mechanism was proposed by the authors. The first example of gold-catalyzed ring-opening addition of cyclopropenes has been developed by Lee’s group [31][32]. The reaction of alkyl-disubstituted cyclopropene 36 with a

• bond. Liu et al. has developed two highly stereoselective cationic gold(I)-catalyzed tandem cyclization reactions of alkynylindoles 322 [160]. The reaction proceeds with remarkable retention of chirality and allows the efficient enantioselective synthesis of polycyclic indolines 327 from the

Mitomycins syntheses: a recent update

• Jean-Christophe Andrez

Beilstein J. Org. Chem. 2009, 5, No. 33, doi:10.3762/bjoc.5.33

• protecting group at C9 which, upon liberation, would reveal the C9–C10 double bond found in mitomycin K. Applying the same radical process depicted in Scheme 27 with substrate 101, a tandem cyclization was observed to afford pentacycle 102. The basic pyrrolidine nitrogen was protected as its N-oxide and the