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Search for "thioesterase" in Full Text gives 29 result(s) in Beilstein Journal of Organic Chemistry.

The regulation and biosynthesis of antimycins

  • Ryan F. Seipke and
  • Matthew I. Hutchings

Beilstein J. Org. Chem. 2013, 9, 2556–2563, doi:10.3762/bjoc.9.290

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  • , ketosynthase; AT, acyltransferase; ACP, acyl carrier protein; TE, thioesterase; *AntP is a pathway-specific kynureninase that is encoded by L- and I-form ant gene clusters. σAntA comprises a new subfamily of ECF RNA polymerase σ factors. σAntA amino acid sequences were aligned to amino acid sequences of random
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Published 19 Nov 2013

Quantification of N-acetylcysteamine activated methylmalonate incorporation into polyketide biosynthesis

  • Stephan Klopries,
  • Uschi Sundermann and
  • Frank Schulz

Beilstein J. Org. Chem. 2013, 9, 664–674, doi:10.3762/bjoc.9.75

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  • ][7][8]. Abbreviations: AT: acyltransferase, ACP: acyl carrier protein, KS: ketosynthase, KR: ketoreductase, DH: dehydratase, ER: enoylreductase, TE: thioesterase. Structures of erythromycin (left) and rapamycin (right). In this experiment both compounds were labeled in their methyl side chains with
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Published 05 Apr 2013

Novel fatty acid methyl esters from the actinomycete Micromonospora aurantiaca

  • Jeroen S. Dickschat,
  • Hilke Bruns and
  • Ramona Riclea

Beilstein J. Org. Chem. 2011, 7, 1697–1712, doi:10.3762/bjoc.7.200

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  • , will be used here for the complete bacterial FA biosynthetic machinery for reasons of brevity and simplicity). Product release from the ACP is achieved by action of a thioesterase (TE) to provide the unbound FA. The combination of an acetyl-CoA starter and malonyl-CoA elongators always leads to
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Published 20 Dec 2011

Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes

  • Jan-Christoph Kehr,
  • Douglas Gatte Picchi and
  • Elke Dittmann

Beilstein J. Org. Chem. 2011, 7, 1622–1635, doi:10.3762/bjoc.7.191

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  • [27], the exact roles of AerE and AerF remain to be elucidated (Figure 4B). The succeeding NRPS adenylation domain is then directly activating Choi as a substrate. The aeruginoside assembly line does not contain a thioesterase or reductase domain [26]. It is thus currently unclear how the final
  • AnaG for chain extension and is followed by chain release, which is expected to be catalyzed by the type II thioesterase AnaA. The reaction scheme as proposed would yield 11-carboxyanatoxin-a and 11-carboxyhomoanatoxin-a. Either a spontaneous or an enzymatically catalyzed decarboxylation step is thus
  • studied, PatD is a single ATP-dependent enzyme not requiring an additional oxidase enzyme [60]. The PatG protease encoded by the cluster was shown to macrocyclize diverse substrates by a mechanism closely resembling the thioesterase-catalyzed chemistry of most NRPS systems [61]. Several related pathways
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Published 05 Dec 2011
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