Beilstein J. Org. Chem.2010,6, No. 6, doi:10.3762/bjoc.6.6
-substituted 1,3-diketones 17 and their derivatives are of great interest. Given that the alkylation typically requires stoichiometric amounts of a base and a toxic alkyl halide the development of an efficient environmentally benign route to 2-alkylated pentanediones 17a–c employing simply benzyl-, allyl- or
formation of a quaternary carbon atom was possible. Although the product was isolated in lower yields (Scheme 17). Subsequently this method was expanded to other nucleophiles, such as 1,3-diketones [60].
Mirroring the Bi(OTf)3-catalyzed method, Hua et al. developed a BiCl3-catalyzed synthesis of 1,1
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Graphical Abstract
Scheme 1:
AlCl3-mediated reaction between amyl chloride and benzene as developed by Friedel and Crafts.