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Search for "Sonogashira reaction" in Full Text gives 52 result(s) in Beilstein Journal of Organic Chemistry.

Recent progress on the total synthesis of acetogenins from Annonaceae

  • Nianguang Li,
  • Zhihao Shi,
  • Yuping Tang,
  • Jianwei Chen and
  • Xiang Li

Beilstein J. Org. Chem. 2008, 4, No. 48, doi:10.3762/bjoc.4.48

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Published 05 Dec 2008

Facile synthesis of two diastereomeric indolizidines corresponding to the postulated structure of alkaloid 5,9E- 259B from a Bufonid toad (Melanophryniscus)

  • Angela Nelson,
  • H. Martin Garraffo,
  • Thomas F. Spande,
  • John W. Daly and
  • Paul J. Stevenson

Beilstein J. Org. Chem. 2008, 4, No. 6, doi:10.1186/1860-5397-4-6

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  • -vinyl iodide with a selectivity of 97:3. Finally, Sonogashira reaction [50] of the vinyl iodide with trimethylsilylacetylene followed by removal of the trimethylsilyl group gave synthetic 7. At this stage the C8 diastereoisomers were separated by flash chromatography, though the minor component was
  • contaminated with triphenyl phosphine / phosphine oxide residue from the Sonogashira reaction. The two synthetic C8 diastereoisomers were compared to natural 5,9E-259B present in the alkaloid fraction obtained from a bufonid toad, Melanophryniscus stelzneri [51]. The GC mass spectra of the three compounds were
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Published 21 Jan 2008
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