Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds

• Kieron M. G. O’Connell,
• Monica Díaz-Gavilán,
• Warren R. J. D. Galloway and
• David R. Spring

Beilstein J. Org. Chem. 2012, 8, 850–860, doi:10.3762/bjoc.8.95

• particular reference to the synthesis of polycyclic alkaloid scaffolds. Keywords: alkaloids; cascade reactions; chemical diversity; diversity-oriented synthesis; Lewis acid catalysis; two-directional synthesis; Introduction Diversity-oriented synthesis (DOS) aims to prepare structurally diverse compound

Recent developments in chemical diversity

• John A. Porco Jr

Beilstein J. Org. Chem. 2012, 8, 827–828, doi:10.3762/bjoc.8.92

• John A. Porco Jr Boston University, Department of Chemistry, 590 Commonwealth Avenue, Boston MA 02215, USA 10.3762/bjoc.8.92 Keywords: chemical diversity; Diversity-oriented synthesis (DOS) is an important field involving the synthesis of libraries of diverse small molecules for applications

• molecules obtained from DOS compound collections [1][2]. This Thematic Series of the Beilstein Journal of Organic Chemistry attempts to capture recent developments in the area of chemical diversity and highlights the development of chemical reaction methodologies, the construction of novel chemotypes, and

• participating contributions in the Thematic Series, involves the development of novel reaction methodologies as a means to access or discover new “chemotypes”. In this way, organic chemists are empowered by the paradigm of “chemical diversity as a function of novel chemical reactions”. “Recent developments in

Gold(I)-catalyzed synthesis of γ-vinylbutyrolactones by intramolecular oxaallylic alkylation with alcohols

• Michel Chiarucci,
• Mirko Locritani,
• Gianpiero Cera and
• Marco Bandini

Beilstein J. Org. Chem. 2011, 7, 1198–1204, doi:10.3762/bjoc.7.139

• activation of allylic alcohols [27][28][29][30][31] with esters [32][33][34][35][36][37]. In this direction, we targeted malonyl alcohols 1 as a readily available class of model acyclic precursors to create chemical diversity through an oxaallylic ring-closing reaction (Figure 1). It should be noted that the