Coupled chemo(enzymatic) reactions in continuous flow

• Ruslan Yuryev,
• Simon Strompen and
• Andreas Liese

Beilstein J. Org. Chem. 2011, 7, 1449–1467, doi:10.3762/bjoc.7.169

• clustering the enzymes of a given metabolic pathway. Moreover, the clustered enzymes usually form supramolecular complexes enabling so-called “substrate channeling”, where intermediates of sequential metabolic steps are not released into the cytoplasm, but instead are “channeled” from one enzyme to another