Synthesis of trifunctional cyclo-β-tripeptide templates

• Frank Stein,
• Tahir Mehmood,
• Tilman Plass,
• Javid H. Zaidi and
• Ulf Diederichsen

Beilstein J. Org. Chem. 2012, 8, 1576–1583, doi:10.3762/bjoc.8.180

• hydrazide linker [11]. Together with a convenient and efficient purification procedure, this method is beneficial with respect to yield and speed of the synthesis. Further, an orthogonal protection strategy was introduced to equip the β-peptide template with three different functional molecules allowing

Syntheses and applications of furanyl-functionalised 2,2’:6’,2’’-terpyridines

• Jérôme Husson and
• Michael Knorr

Beilstein J. Org. Chem. 2012, 8, 379–389, doi:10.3762/bjoc.8.41

• important requirement for sensitizers to be used in DSSC [6]. Conclusion This short review demonstrates that the combination of the furan heterocycle and the terpyridine ligand leads to a series of quite versatile functional molecules. The attached furan ring serves mainly as a precursor to carboxylic acid

Advances in synthetic approach to and antifungal activity of triazoles

• Kumari Shalini,
• Nitin Kumar,
• Sushma Drabu and
• Pramod Kumar Sharma

Beilstein J. Org. Chem. 2011, 7, 668–677, doi:10.3762/bjoc.7.79

• well as in increasing solubility [20]. Moreover, triazoles can function as attractive linker units which could connect two pharmacophores to give an innovative bifunctional drug, and thus have become increasingly useful and important in constructing bioactive and functional molecules [21][22][23

Gold-catalyzed heterocyclizations in alkynyl- and allenyl-β-lactams

• Benito Alcaide and
• Pedro Almendros

Beilstein J. Org. Chem. 2011, 7, 622–630, doi:10.3762/bjoc.7.73

• functional molecules, and therefore, their stereocontrolled synthesis remains an important research area. On the other hand, the recent resplendent age of gold has been accompanied by the emergence of iron salts as powerful alternatives in view of their inexpensiveness and environmental friendliness [38][39

Expanding the gelation properties of valine-based 3,5-diaminobenzoate organogelators with N-alkylurea functionalities

• Hak-Fun Chow and
• Chin-Ho Cheng

Beilstein J. Org. Chem. 2010, 6, 1015–1021, doi:10.3762/bjoc.6.114

• Hak-Fun Chow Chin-Ho Cheng Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR The Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR Institute of Molecular Functional Materials, Areas of Excellence Scheme

Synthesis, electronic properties and self-assembly on Au{111} of thiolated (oligo)phenothiazines

• Adam W. Franz,
• Svetlana Stoycheva,
• Michael Himmelhaus and
• Thomas J. J. Müller

Beilstein J. Org. Chem. 2010, 6, No. 72, doi:10.3762/bjoc.6.72

• gold substrates to solutions of sulfur functionalized molecules [7][8][9][10][11][12][13][14]. These “alligator-clips” [15][16][17] are able to bind functional molecules covalently to gold{111}-surfaces. Phenyl derivatives [18][19], conjugated bi- [18][20] and oligophenyls [18][20][21], oligothiophenes

The C–F bond as a conformational tool in organic and biological chemistry

• Luke Hunter

Beilstein J. Org. Chem. 2010, 6, No. 38, doi:10.3762/bjoc.6.38

• conformational tool for the synthesis of shape-controlled functional molecules. This review will begin by describing some general aspects of the C–F bond and the various conformational effects associated with C–F bonds (i.e. dipole–dipole interactions, charge–dipole interactions and hyperconjugation). Examples

• of functional molecules that exploit these conformational effects will then be presented, drawing from a diverse range of molecules including pharmaceuticals, organocatalysts, liquid crystals and peptides. Keywords: conformation; functional molecules; organofluorine chemistry; stereochemistry

• on examples of shape-controlled functional molecules that exploit the C–F bond as a conformational tool. Bioactive small molecules Despite being the most abundant halogen in the Earth’s crust, fluorine is almost completely absent from natural products chemistry [16]. However, in contrast to the

Diels- Alder reactions using 4,7-dioxygenated indanones as dienophiles for regioselective construction of oxygenated 2,3-dihydrobenz[f]indenone skeleton

• Natsuno Etomi,
• Takuya Kumamoto,
• Waka Nakanishi and
• Tsutomu Ishikawa

Beilstein J. Org. Chem. 2008, 4, No. 15, doi:10.3762/bjoc.4.15

• applicable to not only synthesis of other natural product but also preparation of newly designed functional molecules. The structure of kinamycins. Selected HMBC correlations (lines) and NOE enhancements (dash) on 21 (a) and on 22 (b). Selected HMBC correlations (a) and NOE enhancements (b) on the ring

Aroylketene dithioacetal chemistry: facile synthesis of 4-aroyl- 3-methylsulfanyl- 2-tosylpyrroles from aroylketene dithioacetals and TosMIC

• H. Surya Prakash Rao and
• S. Sivakumar

Beilstein J. Org. Chem. 2007, 3, No. 31, doi:10.1186/1860-5397-3-31

• possible. [3] Since alkylsulfanyl groups are good leaving groups, subsequent to the attack of a nucleophile, one of the alkylsulfanyl groups of the intermediate leave to regenerate the conjugated system. Being polarized alkenes the AKDTAs also react with bi-functional molecules having nucleophilic and