Search results

Search for "molecular recognition" in Full Text gives 157 result(s) in Beilstein Journal of Organic Chemistry.

Molecular recognition using tetralactam macrocycles with parallel aromatic sidewalls

  • Dong-Hao Li and
  • Bradley D. Smith

Beilstein J. Org. Chem. 2019, 15, 1086–1095, doi:10.3762/bjoc.15.105

Graphical Abstract
PDF
Album
Review
Published 09 May 2019

Fabrication, characterization and adsorption properties of cucurbit[7]uril-functionalized polycaprolactone electrospun nanofibrous membranes

  • Changzhong Chen,
  • Fengbo Liu,
  • Xiongzhi Zhang,
  • Zhiyong Zhao and
  • Simin Liu

Beilstein J. Org. Chem. 2019, 15, 992–999, doi:10.3762/bjoc.15.97

Graphical Abstract
  • ][23][24]. Through hydrophobic effects, ion–dipole interactions, and/or hydrogen bonding, CB[n]s show selective molecular recognition properties towards cationic and neutral guests [25][26]. In the last two decades, CB[n]s have been used for a variety of applications including supramolecular catalysis
PDF
Album
Supp Info
Letter
Published 29 Apr 2019

Mechanochemistry of supramolecules

  • Anima Bose and
  • Prasenjit Mal

Beilstein J. Org. Chem. 2019, 15, 881–900, doi:10.3762/bjoc.15.86

Graphical Abstract
  • ]. Supramolecular catalysis The concept of supramolecular catalysis mainly is based on the use of supramolecular chemistry, molecular recognition, host–guest chemistry, etc. for catalysis [96]. The field originated with the understanding of enzymatic system which is conceptually different from traditional organic
PDF
Album
Review
Published 12 Apr 2019

Dispersion interactions

  • Peter R. Schreiner

Beilstein J. Org. Chem. 2018, 14, 3076–3077, doi:10.3762/bjoc.14.286

Graphical Abstract
  • but it is certainly attenuated [8]. We are still in the process of understanding just by how much. LD is a driving force for molecular aggregation that plays a key role in the thermodynamic stability, molecular recognition, chemical selectivity through transition-state stabilization, protein folding
PDF
Album
Editorial
Published 18 Dec 2018

Microwave-assisted synthesis of biologically relevant steroidal 17-exo-pyrazol-5'-ones from a norpregnene precursor by a side-chain elongation/heterocyclization sequence

  • Gergő Mótyán,
  • László Mérai,
  • Márton Attila Kiss,
  • Zsuzsanna Schelz,
  • Izabella Sinka,
  • István Zupkó and
  • Éva Frank

Beilstein J. Org. Chem. 2018, 14, 2589–2596, doi:10.3762/bjoc.14.236

Graphical Abstract
  • , keto–enol tautomerism can be challenging and is of special importance in biological systems, chemical reactivity, and molecular recognition [18]. The tautomeric equilibrium in solution is strongly influenced by the substitution pattern of the heterocyclic ring, the polarity and protic nature of the
PDF
Album
Supp Info
Full Research Paper
Published 08 Oct 2018

Synthesis of a water-soluble 2,2′-biphen[4]arene and its efficient complexation and sensitive fluorescence enhancement towards palmatine and berberine

  • Xiayang Huang,
  • Xinghua Zhang,
  • Tianxin Qian,
  • Junwei Ma,
  • Lei Cui and
  • Chunju Li

Beilstein J. Org. Chem. 2018, 14, 2236–2241, doi:10.3762/bjoc.14.198

Graphical Abstract
  • = (2.29 ± 0.27) × 106 M−1) is 3.9 times larger than that of P (Ka = (5.87 ± 0.24) × 105 M−1). Keywords: berberine; biphenarenes; host–guest complexes; molecular recognition; palmatine; Introduction Host–guest chemistry in water is significantly important due to its extensive applications in biology
PDF
Album
Supp Info
Full Research Paper
Published 27 Aug 2018

Synthesis and post-functionalization of alternate-linked-meta-para-[2n.1n]thiacyclophanes

  • Wout De Leger,
  • Koen Adriaensen,
  • Koen Robeyns,
  • Luc Van Meervelt,
  • Joice Thomas,
  • Björn Meijers,
  • Mario Smet and
  • Wim Dehaen

Beilstein J. Org. Chem. 2018, 14, 2190–2197, doi:10.3762/bjoc.14.192

Graphical Abstract
  • molecular recognition of organic compounds as well as metals. Herein, we report the selective and high-yielding synthesis of novel alternate-linked-meta-para-thiacyclophanes. These novel thiacyclophanes are selectively synthesized in high-yielding procedures. Furthermore, post-functionalization of the
  • cyclophanes is formed by thiacyclophanes, in which the thioether linkages impose less conformational strain and which have an increased cavity size compared to other (oxa/aza)cyclophanes. Thiacalix[n]arenes are among the most widely known thiacyclophanes with significant ability for molecular recognition [5
  • was further analysed by X-ray diffraction. Results and Discussion Macrocyclization Macrocyclization and post-functionalization of cyclophanes is of high interest for the development of various applications in molecular recognition. Based on our previous one-pot procedure towards homothiacalixarenes
PDF
Album
Supp Info
Full Research Paper
Published 22 Aug 2018

Calix[6]arene-based atropoisomeric pseudo[2]rotaxanes

  • Carmine Gaeta,
  • Carmen Talotta and
  • Placido Neri

Beilstein J. Org. Chem. 2018, 14, 2112–2124, doi:10.3762/bjoc.14.186

Graphical Abstract
  • bis(benzylalkylammonium) axle [19], where the stereoselective formation of the pseudo[3]rotaxane with endo-alkyl orientation VIII was observed [19]. Calixarene macrocycles [22] have found numerous applications in several areas of supramolecular chemistry, such as (bio)molecular recognition [23] and
PDF
Album
Supp Info
Full Research Paper
Published 14 Aug 2018

Synthesis and supramolecular self-assembly of glutamic acid-based squaramides

  • Juan V. Alegre-Requena,
  • Marleen Häring,
  • Isaac G. Sonsona,
  • Alex Abramov,
  • Eugenia Marqués-López,
  • Raquel P. Herrera and
  • David Díaz Díaz

Beilstein J. Org. Chem. 2018, 14, 2065–2073, doi:10.3762/bjoc.14.180

Graphical Abstract
  • asymmetric catalysis and molecular recognition [5][6]. Besides, squaramides present a dual ability to recognize anions and cations through hydrogen bonding interactions, acting as ion sensors and transmembrane anion transporters [7]. This property has been crucial for the development of new drugs [8][9
PDF
Album
Supp Info
Full Research Paper
Published 06 Aug 2018

Synthesis of new p-tert-butylcalix[4]arene-based polyammonium triazolyl amphiphiles and their binding with nucleoside phosphates

  • Vladimir A. Burilov,
  • Guzaliya A. Fatikhova,
  • Mariya N. Dokuchaeva,
  • Ramil I. Nugmanov,
  • Diana A. Mironova,
  • Pavel V. Dorovatovskii,
  • Victor N. Khrustalev,
  • Svetlana E. Solovieva and
  • Igor S. Antipin

Beilstein J. Org. Chem. 2018, 14, 1980–1993, doi:10.3762/bjoc.14.173

Graphical Abstract
  • was elaborated for the naked-eye detection of ADP with a detection limit of 0.5 mM. Keywords: ADP; amphiphile; ATP; calix[4]arene; CuAAC; eosin Y probe; molecular recognition; polydiacetylene; self-assembly; triazole; Introduction During the last two decades many researcher groups have paid much
PDF
Album
Supp Info
Full Research Paper
Published 31 Jul 2018

Diazirine-functionalized mannosides for photoaffinity labeling: trouble with FimH

  • Femke Beiroth,
  • Tomas Koudelka,
  • Thorsten Overath,
  • Stefan D. Knight,
  • Andreas Tholey and
  • Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2018, 14, 1890–1900, doi:10.3762/bjoc.14.163

Graphical Abstract
  • X-ray crystallography, studies in solution add valuable information in molecular recognition studies as they take molecular dynamics as well as solvent effects into consideration. In the latter respect, photoaffinity labeling has evolved as a useful tool for studies under physiological conditions [1
PDF
Album
Supp Info
Full Research Paper
Published 24 Jul 2018

Strong binding and fluorescence sensing of bisphosphonates by guanidinium-modified calix[5]arene

  • Jie Gao,
  • Zhe Zheng,
  • Lin Shi,
  • Si-Qi Wu,
  • Hongwei Sun and
  • Dong-Sheng Guo

Beilstein J. Org. Chem. 2018, 14, 1840–1845, doi:10.3762/bjoc.14.157

Graphical Abstract
  • to their facial modification, Prof. Böhmer demonstrated calixarenes as having “(almost) unlimited possibilities” [17]. We have focused on molecular recognition and self-assembly of water-soluble calixarene derivatives for a long time [18][19][20][21][22][23][24], directed by exploring biomedical
PDF
Album
Supp Info
Full Research Paper
Published 19 Jul 2018

Host–guest complexes of conformationally flexible C-hexyl-2-bromoresorcinarene and aromatic N-oxides: solid-state, solution and computational studies

  • Rakesh Puttreddy,
  • Ngong Kodiah Beyeh,
  • S. Maryamdokht Taimoory,
  • Daniel Meister,
  • John F. Trant and
  • Kari Rissanen

Beilstein J. Org. Chem. 2018, 14, 1723–1733, doi:10.3762/bjoc.14.146

Graphical Abstract
  • properties by tuning the structure of the interacting partners. Over the past decade, the N-oxide family has attracted the attention of the H–G community in molecular recognition processes [33][34][35]. In order to tune the resorcinarene-PyNO H–G recognition events at the molecular level, a better
PDF
Album
Supp Info
Full Research Paper
Published 10 Jul 2018

The phenyl vinyl ether–methanol complex: a model system for quantum chemistry benchmarking

  • Dominic Bernhard,
  • Fabian Dietrich,
  • Mariyam Fatima,
  • Cristóbal Pérez,
  • Hannes C. Gottschalk,
  • Axel Wuttke,
  • Ricardo A. Mata,
  • Martin A. Suhm,
  • Melanie Schnell and
  • Markus Gerhards

Beilstein J. Org. Chem. 2018, 14, 1642–1654, doi:10.3762/bjoc.14.140

Graphical Abstract
  • hydrogen bonds; Introduction The balance of different noncovalent interactions is crucial for chemical and biochemical processes as it controls molecular recognition and aggregation [1][2][3][4][5][6]. In order to gain a deeper understanding of these processes, knowledge on exact structural arrangements
PDF
Album
Supp Info
Full Research Paper
Published 02 Jul 2018

A conformationally adaptive macrocycle: conformational complexity and host–guest chemistry of zorb[4]arene

  • Liu-Pan Yang,
  • Song-Bo Lu,
  • Arto Valkonen,
  • Fangfang Pan,
  • Kari Rissanen and
  • Wei Jiang

Beilstein J. Org. Chem. 2018, 14, 1570–1577, doi:10.3762/bjoc.14.134

Graphical Abstract
  • [12] is crucial for minimizing the entropy cost in molecular recognition. In contrast, bioreceptors often possess flexible backbone structures and even undergo large amplitude conformational changes upon binding substrates [13][14]. This conformational adaptivity is the basis of the allosteric effects
  • explained by invoking a solvent reorganization during the formation of 18+@ZB4 complex, which is common for reactions taking place in aqueous solution [41]. Conclusion In summary, we systematically studied the guest binding scope, electronic substituent effects and thermodynamic origin on the molecular
  • recognition of ZB4 using NMR, ITC titration and X-ray crystallography. Similar to TA4, ZB4 is able to host a wide range of organic cations. However, in contrast to TA4, ZB4 shows no large amplitude of conformational response to the electronic nature of substituents on the guests, and its binding affinities
PDF
Album
Supp Info
Full Research Paper
Published 27 Jun 2018

Recent applications of chiral calixarenes in asymmetric catalysis

  • Mustafa Durmaz,
  • Erkan Halay and
  • Selahattin Bozkurt

Beilstein J. Org. Chem. 2018, 14, 1389–1412, doi:10.3762/bjoc.14.117

Graphical Abstract
  • upper and/or lower rims of the molecular skeleton, they have been widely used for construction of artificial host molecules and found applications in various fields like molecular recognition, sensing, self-assembly, catalysis, nanoscience, drug delivery and separation science [7][8][9][10][11][12][13
PDF
Album
Review
Published 08 Jun 2018

Oligonucleotide analogues with cationic backbone linkages

  • Melissa Meng and
  • Christian Ducho

Beilstein J. Org. Chem. 2018, 14, 1293–1308, doi:10.3762/bjoc.14.111

Graphical Abstract
  • biological mechanisms via sequence-specific molecular recognition makes them highly attractive candidates for drug development. However, their pharmacokinetic properties are problematic and represent a significant hurdle for their therapeutic application. First, the high polarity of ONs, mainly caused by
PDF
Album
Review
Published 04 Jun 2018

An overview of recent advances in duplex DNA recognition by small molecules

  • Sayantan Bhaduri,
  • Nihar Ranjan and
  • Dev P. Arya

Beilstein J. Org. Chem. 2018, 14, 1051–1086, doi:10.3762/bjoc.14.93

Graphical Abstract
  • study their solution-phase self-association characteristics and DNA molecular-recognition properties [17]. The authors showed a measurable difference in solution-phase self-assembly character with enhanced DNA association characteristics by replacing the formamide head group in thiazotropsin A with
PDF
Album
Review
Published 16 May 2018

Recent advances in synthetic approaches for medicinal chemistry of C-nucleosides

  • Kartik Temburnikar and
  • Katherine L. Seley-Radtke

Beilstein J. Org. Chem. 2018, 14, 772–785, doi:10.3762/bjoc.14.65

Graphical Abstract
  • stability, ii) altered hydrogen bonding motifs, and iii) altered molecular recognition properties [25][29][37][58]. Because of these changes, C-nucleosides have been useful in the study of RNA and DNA processing enzymes, as well as drug design efforts and novel supramolecular structures [12][29][59
  • acids. Shown is the monomeric building block of nucleic acids. Changes to the nucleotide structure can affect molecular recognition, as well as structure and function. Formation of oxocarbenium ion during glycosidic bond cleavage in nucleosides [31]. The extent of leaving group stabilization and
PDF
Album
Review
Published 05 Apr 2018

An uracil-linked hydroxyflavone probe for the recognition of ATP

  • Márton Bojtár,
  • Péter Zoltán Janzsó-Berend,
  • Dávid Mester,
  • Dóra Hessz,
  • Mihály Kállay,
  • Miklós Kubinyi and
  • István Bitter

Beilstein J. Org. Chem. 2018, 14, 747–755, doi:10.3762/bjoc.14.63

Graphical Abstract
  • -5’-triphosphate, GTP) and the strong solvation of the chemosensor and the analyte in aqueous media, reducing the association constant of their complex, and through that the sensitivity of the sensor [31][32]. The molecular recognition of nucleotides in most chemosensors is achieved by charged
PDF
Album
Supp Info
Full Research Paper
Published 03 Apr 2018

Enzyme-free genetic copying of DNA and RNA sequences

  • Marilyne Sosson and
  • Clemens Richert

Beilstein J. Org. Chem. 2018, 14, 603–617, doi:10.3762/bjoc.14.47

Graphical Abstract
  • enzymes and ribozymes, relying on solely on base pairing for molecular recognition and chemical reactivity to drive the formation of phosphodiester bonds in aqueous media. This is what is usually referred to as "enzyme-free copying" (Figure 1). Studies on enzyme-free copying of genetic polymers date back
PDF
Album
Review
Published 12 Mar 2018

Structural diversity in the host–guest complexes of the antifolate pemetrexed with native cyclodextrins: gas phase, solution and solid state studies

  • Magdalena Ceborska,
  • Magdalena Zimnicka,
  • Aneta Aniela Kowalska,
  • Kajetan Dąbrowa and
  • Barbara Repeć

Beilstein J. Org. Chem. 2017, 13, 2252–2263, doi:10.3762/bjoc.13.222

Graphical Abstract
  • techniques (NMR, CID-MS, FTIR–ATR and Raman spectroscopy) allows for a deeper and clearer understanding of the molecular recognition of native CDs. Experimental Materials FA (≥97%) was obtained from Sigma-Aldrich and used as disodium salt. PTX-Na2 (≥98%) was obtained from ChemScene (USA). α-, β-, and γ-CDs
PDF
Album
Supp Info
Full Research Paper
Published 25 Oct 2017

Dialkyl dicyanofumarates and dicyanomaleates as versatile building blocks for synthetic organic chemistry and mechanistic studies

  • Grzegorz Mlostoń and
  • Heinz Heimgartner

Beilstein J. Org. Chem. 2017, 13, 2235–2251, doi:10.3762/bjoc.13.221

Graphical Abstract
  • observed by 1H NMR spectroscopy [8]. Similar systems were prepared on solid phase and used as a new molecular recognition system [44]. The [4 + 2]-cycloaddition reactions of E- and Z-1b with electron-rich 1,3-dienes have been studied extensively by Sustmann and collaborators. Thus, 1-methoxybuta-1,3-diene
PDF
Album
Review
Published 24 Oct 2017

Superstructures with cyclodextrins: Chemistry and applications IV

  • Gerhard Wenz

Beilstein J. Org. Chem. 2017, 13, 2157–2159, doi:10.3762/bjoc.13.215

Graphical Abstract
  • Beilstein Journal of Organic Chemistry also provides further insights into the synthesis and properties of CD superstructures, covering many aspects such as catalysis, molecular recognition, colloids, polyrotaxanes, drug delivery and more. Gerhard Wenz Saarbrücken, September 2017
PDF
Editorial
Published 18 Oct 2017

Molecular recognition of N-acetyltryptophan enantiomers by β-cyclodextrin

  • Spyros D. Chatziefthimiou,
  • Mario Inclán,
  • Petros Giastas,
  • Athanasios Papakyriakou,
  • Konstantina Yannakopoulou and
  • Irene M. Mavridis

Beilstein J. Org. Chem. 2017, 13, 1572–1582, doi:10.3762/bjoc.13.157

Graphical Abstract
PDF
Album
Supp Info
Full Research Paper
Published 09 Aug 2017
Other Beilstein-Institut Open Science Activities