One-pot gold-catalyzed synthesis of 3-silylethynyl indoles from unprotected o-alkynylanilines

• Jonathan P. Brand,
• Clara Chevalley and
• Jérôme Waser

Beilstein J. Org. Chem. 2011, 7, 565–569, doi:10.3762/bjoc.7.65

• -alkynylanilines can be followed by 1,4-addition to enones [15][16], iodination [17] or reaction with 1,3-dicarbonyl compounds [18]. Perumal recently demonstrated that aldehydes and nitroalkenes can be used as electrophilic partners [19][20]. Triple bonds can also serve as a second electrophile for the

The C–F bond as a conformational tool in organic and biological chemistry

• Luke Hunter

Beilstein J. Org. Chem. 2010, 6, No. 38, doi:10.3762/bjoc.6.38

• -generation catalyst for the Stetter reaction between aryl aldehydes (e.g. 47) and nitroalkenes (e.g. 48). Superficially, it seems that the bulky isopropyl group of 49 is solely responsible for the enantioselectivity of this reaction. However, the shape of the bicyclic ring system might also play a role and