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Search for "one-pot process" in Full Text gives 66 result(s) in Beilstein Journal of Organic Chemistry.

An organocatalytic route to 2-heteroarylmethylene decorated N-arylpyrroles

  • Alexandre Jean,
  • Jérôme Blanchet,
  • Jacques Rouden,
  • Jacques Maddaluno and
  • Michaël De Paolis

Beilstein J. Org. Chem. 2013, 9, 1480–1486, doi:10.3762/bjoc.9.168

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  •  3, the methodology was next attempted in a one-pot process. Hence, the transformation of aldehyde 1a and imine 2a into pyrrolidine 4a was followed by the introduction of DBU leading to pyrrole 5a in 26% yield. However, proceeding stepwise and isolating the pyrrolidine 4a by a simple filtration on
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Published 24 Jul 2013

Carbolithiation of N-alkenyl ureas and N-alkenyl carbamates

  • Julien Lefranc,
  • Alberto Minassi and
  • Jonathan Clayden

Beilstein J. Org. Chem. 2013, 9, 628–632, doi:10.3762/bjoc.9.70

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  • carbamates were deprotected by treatment with CF3CO2H in a one-pot process, to provide the amines 13a–c in good yields over the two steps (Table 4, entries 4–6). In every case, the amine 13 was obtained as a single diastereomer, which we assume, by analogy with the reactions of the equivalent ureas, to be
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Published 28 Mar 2013

Automated three-component synthesis of a library of γ-lactams

  • Erik Fenster,
  • David Hill,
  • Oliver Reiser and
  • Jeffrey Aubé

Beilstein J. Org. Chem. 2012, 8, 1804–1813, doi:10.3762/bjoc.8.206

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  • efficient for parallel synthesis. If N-phenylmaleimide (1{1}) was to be used as a limiting reagent and propionaldehyde (2{1}) and aniline (4{1}) were used (with 4{1} in excess relative to 2{1}), then at the end of the one-pot process we should be left with the desired γ-lactam 6{1,1,1} and with only amines
  • parallel library synthesis. Improvements to the chemistry over the previous method include the introduction of asymmetry in the form of an organocatalyzed Michael addition, the removal of the main by-products and excess reagents by using an aqueous acid wash, and the optimization for a one-pot process
  • , Germany 10.3762/bjoc.8.206 Abstract A three-component method for the synthesis of γ-lactams from commercially available maleimides, aldehydes, and amines was adapted to parallel library synthesis. Improvements to the chemistry over previous efforts include the optimization of the method to a one-pot
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Published 19 Oct 2012

Highly selective synthesis of (E)-alkenyl-(pentafluorosulfanyl)benzenes through Horner–Wadsworth–Emmons reaction

  • George Iakobson and
  • Petr Beier

Beilstein J. Org. Chem. 2012, 8, 1185–1190, doi:10.3762/bjoc.8.131

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  • by a two-step one-pot process, involving VNS reaction in DMF with a three-fold excess of t-BuOK (−60 °C, 10 min), followed by the addition of benzaldehyde (1.5 equiv) and warming of the reaction mixture to 50 °C (Table 1, entry 1). These conditions provided the expected 5a in good GCMS yield and high
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Published 25 Jul 2012

A general and facile one-pot process of isothiocyanates from amines under aqueous conditions

  • Nan Sun,
  • Bin Li,
  • Jianping Shao,
  • Weimin Mo,
  • Baoxiang Hu,
  • Zhenlu Shen and
  • Xinquan Hu

Beilstein J. Org. Chem. 2012, 8, 61–70, doi:10.3762/bjoc.8.6

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  • particularly for highly electron-deficient substrates. This novel and economical method is suitable for scale-up activities. Keywords: aqueous conditions; cyanuric acid; isothiocyanates; one-pot process; organic synthesis; primary amines; Introduction Isothiocyanates are a class of heteroallenic compounds
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Published 10 Jan 2012

Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine

  • Jessica Baiget,
  • Sabin Llona-Minguez,
  • Stuart Lang,
  • Simon P. MacKay,
  • Colin J. Suckling and
  • Oliver B. Sutcliffe

Beilstein J. Org. Chem. 2011, 7, 1407–1411, doi:10.3762/bjoc.7.164

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  • analogues containing the carboline heterocyclic moiety. A manganese dioxide mediated one-pot method starting with an activated alcohol and consisting of alcohol oxidation, Pictet–Spengler cyclisation, and oxidative aromatisation, offers a convenient process that allows access to β-carbolines. This one-pot
  • process for the preparation of methyl 9H-pyrido[3,4-b]indole-1-carboxylate has subsequently been used as the key step in the synthesis of alangiobussinine and a closely related analogue. Keywords: alkaloid synthesis; carboline; heterocycle; oxidation; tandem reaction; Introduction Carbolines are an
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Published 12 Oct 2011

Amines as key building blocks in Pd-assisted multicomponent processes

  • Didier Bouyssi,
  • Nuno Monteiro and
  • Geneviève Balme

Beilstein J. Org. Chem. 2011, 7, 1387–1406, doi:10.3762/bjoc.7.163

Graphical Abstract
  • are formed, they immediately react with hydrazine to form pyrazole by a specific rate acceleration in the one-pot process [16]. The Sonogashira cross-coupling of acid chlorides with terminal alkynes has also been demonstrated as a valuable tool to generate, in situ, ynones bearing a pendant amine
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Published 10 Oct 2011

One-pot Diels–Alder cycloaddition/gold(I)-catalyzed 6-endo-dig cyclization for the synthesis of the complex bicyclo[3.3.1]alkenone framework

  • Boubacar Sow,
  • Gabriel Bellavance,
  • Francis Barabé and
  • Louis Barriault

Beilstein J. Org. Chem. 2011, 7, 1007–1013, doi:10.3762/bjoc.7.114

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  • [3.3.1]alkanones in yields ranging from 48–93%. Keywords: bicyclo[3.3.1]nonenone; carbocyclization; Diels–Alder; gold catalysis; one-pot process; Introduction Highly oxygenated and densely substituted carbon-bridged medium sized rings such as 1 are commonly found in nature as structural frameworks of
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Published 22 Jul 2011

A practical route to tertiary diarylmethylamides or -carbamates from imines, organozinc reagents and acyl chlorides or chloroformates

  • Erwan Le Gall,
  • Antoine Pignon and
  • Thierry Martens

Beilstein J. Org. Chem. 2011, 7, 997–1002, doi:10.3762/bjoc.7.112

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  • to iminium ions. Consequently, we report herein the use of primary amines in a sequential one-pot process, based on the preliminary activation of an aldimine with an acyl chloride or a chloroformate, and the subsequent trapping of the resulting acyliminium ion with an aromatic organozinc reagent, to
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Published 20 Jul 2011

Complete transfer of chirality in an intramolecular, thermal [2 + 2] cycloaddition of allene-ynes to form non-racemic spirooxindoles

  • Kay M. Brummond and
  • Joshua M. Osbourn

Beilstein J. Org. Chem. 2011, 7, 601–605, doi:10.3762/bjoc.7.70

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  • spirooxindole-containing skeletons 2 in a two-step one-pot process from propargyl acetates 1 [4] (Scheme 1). Inspired by this rapid entry into the molecularly complex substructure 2, and the structural similarity to welwitindolinone A isonitrile (3), we became interested in the synthesis of chiral non-racemic
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Published 12 May 2011

One-pot gold-catalyzed synthesis of 3-silylethynyl indoles from unprotected o-alkynylanilines

  • Jonathan P. Brand,
  • Clara Chevalley and
  • Jérôme Waser

Beilstein J. Org. Chem. 2011, 7, 565–569, doi:10.3762/bjoc.7.65

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  • access to 3-silylalkynyl indoles. To the best of our knowledge, this is the first example of a one-pot process combining a Au(III) and a Au(I) catalyst. Findings 2-Alkynylanilines 2 can be efficiently prepared from 2-iodoanilines 4 and terminal alkynes via Sonogashira reaction with Et3N as solvent
  • . Importantly, this transformation did not require prior aniline protection and proceeded under mild conditions. This methodology represents the first example of the sequential addition of Au(III) and Au(I) catalysts for a one-pot process. Experimental General procedure for the synthesis of 2-alkynylanilines 2
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Published 04 May 2011

Miniemulsion polymerization as a versatile tool for the synthesis of functionalized polymers

  • Daniel Crespy and
  • Katharina Landfester

Beilstein J. Org. Chem. 2010, 6, 1132–1148, doi:10.3762/bjoc.6.130

Graphical Abstract
  • prepolymers are sufficiently hydrophilic. Polymerizations in non-aqueous inverse miniemulsions are even possible as was previously demonstrated [79]. Polyurethanes free from any urea could be hence produced in non-aqueous inverse miniemulsions in a one-pot process [110]. In this case the miniemulsions of
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Published 01 Dec 2010

Diastereoselective functionalisation of benzo-annulated bicyclic sultams: Application for the synthesis of cis-2,4-diarylpyrrolidines

  • Susan Kelleher,
  • Pierre-Yves Quesne and
  • Paul Evans

Beilstein J. Org. Chem. 2009, 5, No. 69, doi:10.3762/bjoc.5.69

Graphical Abstract
  • reaction was simply stirred under a hydrogen atmosphere in order to afford the corresponding saturated bicycles 6a and 6b in yields of 61 and 52% respectively. In terms of efficiency this one-pot process is competitive compared with those from the original two-step, two-pot process (Scheme 2
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Published 25 Nov 2009

Mitomycins syntheses: a recent update

  • Jean-Christophe Andrez

Beilstein J. Org. Chem. 2009, 5, No. 33, doi:10.3762/bjoc.5.33

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Published 08 Jul 2009

Synthesis of densely functionalized enantiopure indolizidines by ring- closing metathesis (RCM) of hydroxylamines from carbohydrate- derived nitrones

  • Marco Bonanni,
  • Marco Marradi,
  • Francesca Cardona,
  • Stefano Cicchi and
  • Andrea Goti

Beilstein J. Org. Chem. 2007, 3, No. 44, doi:10.1186/1860-5397-3-44

Graphical Abstract
  • diastereomeric mixture, while 6 was obtained from an equimolecular mixture with its diastereoisomer.[24] Assignment of configuration has been secured by comparison with the double adducts of the one-pot process and by careful NMR studies of the final cyclic products after RCM. The scarce stereoselectivity of the
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Published 12 Dec 2007

The vicinal difluoro motif: The synthesis and conformation of erythro- and threo- diastereoisomers of 1,2-difluorodiphenylethanes, 2,3-difluorosuccinic acids and their derivatives

  • David O'Hagan,
  • Henry S. Rzepa,
  • Martin Schüler and
  • Alexandra M. Z. Slawin

Beilstein J. Org. Chem. 2006, 2, No. 19, doi:10.1186/1860-5397-2-19

Graphical Abstract
  • pot process with NBS, PPHF and Ag(I)F again proceeded smoothly however it also gave erythro-13 as the major product of the reaction, although with a reduced diastereoisomeric ratio (47% de) more suitable for threo- 13 isolation. The bias towards erythro- 13 in this case is clearly a result of internal
  • benzylic as well as anchimeric stabilisation via phenonium ring formation 18 with the β-phenyl group as illustrated in Scheme 6. Isolation of the minor threo-13 isomer required careful chromatography. In order to improve the synthesis of threo-13 a reaction with cis-stilbene 17 was investigated. The one
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Published 02 Oct 2006
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