Damage of polyesters by the atmospheric free radical oxidant NO₃^•: a product study involving model systems

• Catrin Goeschen and
• Uta Wille

Beilstein J. Org. Chem. 2013, 9, 1907–1916, doi:10.3762/bjoc.9.225

• materials, the chemical mechanism of polymer degradation is by far not fully understood. It has generally been assumed that polymer degradation involves a radical-mediated autoxidation mechanism, which propagates through hydrogen abstraction by an intermediate peroxyl radical ROO•. Although this

Interplay of ortho- with spiro-cyclisation during iminyl radical closures onto arenes and heteroarenes

• Roy T. McBurney and
• John C. Walton

Beilstein J. Org. Chem. 2013, 9, 1083–1092, doi:10.3762/bjoc.9.120

• research initiated spiralling interest by synthetic chemists in iminyl radical-mediated preparations. Recently iminyls have been generated from quite a variety of precursors [10][11][12][13][14][15], and their cyclisations onto arenes [16][17][18][19][20][21] and heteroarenes [22][23][24] have attracted

Synthesis of phenanthridines via palladium-catalyzed picolinamide-directed sequential C–H functionalization

• Ryan Pearson,
• Shuyu Zhang,
• Gang He,
• Nicola Edwards and
• Gong Chen

Beilstein J. Org. Chem. 2013, 9, 891–899, doi:10.3762/bjoc.9.102

• –Hubert condensation [9], radical-mediated reactions [10][11][12][13], metal-catalyzed cross-couplings [14][15][16][17][18], cycloadditions [19], and others [20][21][22]. More recently, methods based on the metal-catalyzed functionalization of carbon–hydrogen (C–H) bonds have also emerged as viable

Bioactive selaginellins from Selaginella tamariscina (Beauv.) Spring

• Chao Yang,
• Yutian Shao,
• Kang Li and
• Wujiong Xia

Beilstein J. Org. Chem. 2012, 8, 1884–1889, doi:10.3762/bjoc.8.217

• selaginellin M (2) and selaginellin (3), with IC50 equal to 28.5 and 33.1 μM, respectively. Over the past few decades, considerable biochemical, physiological and pharmacological evidence has accumulated to support the hypothesis that free-radical-mediated oxidative processes are implicated in various human

Analogues of amphibian alkaloids: total synthesis of (5R,8S,8aS)-(−)-8-methyl- 5-pentyloctahydroindolizine (8-epi-indolizidine 209B) and [(1S,4R,9aS)-(−)-4-pentyloctahydro- 2H-quinolizin- 1-yl]methanol

• Joseph P. Michael,
• Claudia Accone,
• Charles B. de Koning and
• Christiaan W. van der Westhuyzen

Beilstein J. Org. Chem. 2008, 4, No. 5, doi:10.1186/1860-5397-4-5

• alcohol 41 opens up a route to quinolizidine alkaloids containing C-1 methyl substituents (provided, of course, that we can find a better method for deoxygenation, probably by radical-mediated reaction). In addition, alkyl homologues at C-1 should be accessible; one could, for example, replace the alcohol