Bioactive selaginellins from Selaginella tamariscina (Beauv.) Spring

• Chao Yang,
• Yutian Shao,
• Kang Li and
• Wujiong Xia

Beilstein J. Org. Chem. 2012, 8, 1884–1889, doi:10.3762/bjoc.8.217

• selaginellin M (2) and selaginellin (3), with IC50 equal to 28.5 and 33.1 μM, respectively. Over the past few decades, considerable biochemical, physiological and pharmacological evidence has accumulated to support the hypothesis that free-radical-mediated oxidative processes are implicated in various human

Analogues of amphibian alkaloids: total synthesis of (5R,8S,8aS)-(−)-8-methyl- 5-pentyloctahydroindolizine (8-epi-indolizidine 209B) and [(1S,4R,9aS)-(−)-4-pentyloctahydro- 2H-quinolizin- 1-yl]methanol

• Joseph P. Michael,
• Claudia Accone,
• Charles B. de Koning and
• Christiaan W. van der Westhuyzen

Beilstein J. Org. Chem. 2008, 4, No. 5, doi:10.1186/1860-5397-4-5

• alcohol 41 opens up a route to quinolizidine alkaloids containing C-1 methyl substituents (provided, of course, that we can find a better method for deoxygenation, probably by radical-mediated reaction). In addition, alkyl homologues at C-1 should be accessible; one could, for example, replace the alcohol