Mitomycins syntheses: a recent update

• Jean-Christophe Andrez

Beilstein J. Org. Chem. 2009, 5, No. 33, doi:10.3762/bjoc.5.33

• was prepared in 94.7% ee by asymmetric ring opening of the corresponding N-Boc protected meso epoxide using the Jacobsen (salen)Cr(III) complex and TMSN3 [111]. The acetate group was installed on the aromatic using a palladium catalyzed reaction with the silylketene acetal 140 in the presence of

From discovery to production: Scale- out of continuous flow meso reactors

• Peter Styring and
• Ana I. R. Parracho

Beilstein J. Org. Chem. 2009, 5, No. 29, doi:10.3762/bjoc.5.29

• environmental and economic burden on the process. Previously, we have described a series of catalysts based on nickel(II) and palladium(II) that have functionalised salen-acac (salenac) ligands that were functionalised such that they could be covalently bound to organic or inorganic polymer supports [6][7][8][9

Asymmetric reactions in continuous flow

• Xiao Yin Mak,
• Paola Laurino and
• Peter H. Seeberger

Beilstein J. Org. Chem. 2009, 5, No. 19, doi:10.3762/bjoc.5.19

• Co(salen) complex 33 (Scheme 10) [41]. Three consecutive 1 mmol scale runs (20 h each), where a solution of epibromohydrin was continuously circulated through the reactor via a pump, were performed without any loss of enantioselectivity and catalyst activity (76–87% yield, 91–93% ee). A fourth

• using a silica-supported chiral Co(salen) complex [42]. Asymmetric cyclopropanation has also been studied in continuous flow, using monolithic reactors immobilized with chiral PyBox ligands [43][44]. The cyclopropanation of stryrene with ethyldiazoacetate was investigated as a model reaction for this

• dendritic polyglycerol supported Mn-salen catalyst 50, was recently developed in a continuous membrane flow reactor [53]. This type of flow system involves the continuous removal of the product from the high molecular weight macrostructured catalysts by filtration through a nanomembrane (Scheme 14). In this

The first salen- type ligands derived from 3',5'-diamino- 3',5'-dideoxythymidine and -dideoxyxylothymidine and their corresponding copper(II) complexes

• Daniel Koth,
• Michael Gottschaldt,
• Helmar Görls and
• Karolin Pohle

Beilstein J. Org. Chem. 2006, 2, No. 17, doi:10.1186/1860-5397-2-17

• 1H-1H spin spin coupling constants 3J obtained by NMR-studies. Condensation of the amino derivatives with salicylic aldehydes resulted in the corresponding diimines, which represent a new class of chiral salen-type ligands. All ligands formed uncharged stable copper(II) complexes. The structure of 3

• with xylo- as well as ribo-configuration an effective synthesis pathway has been developed. Their corresponding salicylidene imines form stable coordination compounds with copper(II) ions. They represent the first salen type complexes of nucleosides with this substitution pattern. Background Complexes

• 3',5'-diaminothymidines in ribo- and xylo-configuration represent the first nucleosides bearing salen-type chelating units at these positions. With their synthesis a new class of tetradentate chiral ligands with interesting features could be obtained. The chiral sugar moiety is close to the metal