Beilstein J. Org. Chem.2006,2, No. 21, doi:10.1186/1860-5397-2-21
. As expected, oxazoles, thiazoles, pyrazoles, and pyridines are tolerated in this chemistry. In a limited number of cases, functionality (e.g. basic amines, benzimidazoles, indoles, etc.) caused no reaction to occur and only recovered starting materials were isolated (data not shown).
We then shifted
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Graphical Abstract
Figure 1:
Thiazolidine-2,4-dione mimic & chosen lead scaffold.