Shelf-stable electrophilic trifluoromethylating reagents: A brief historical perspective

• Norio Shibata,
• Andrej Matsnev and
• Dominique Cahard

Beilstein J. Org. Chem. 2010, 6, No. 65, doi:10.3762/bjoc.6.65

• showed a clear advantage in the reaction with α-nitro esters; the reaction proceeded smoothly in CH2Cl2 in the presence of a catalytic amount of CuCl2 (Scheme 28) [33]. Interestingly, 2-(2-iodophenyl)propan-2-ol formed as by-product in the reactions of 37 with the substrates could be isolated and

Zeolite catalyzed solvent- free one-pot synthesis of dihydropyrimidin- 2(1H)-ones – A practical synthesis of monastrol

• Mukund G. Kulkarni,
• Sanjay W. Chavhan,
• Mahadev P. Shinde,
• Dnyaneshwar D. Gaikwad,
• Ajit S. Borhade,
• Attrimuni P. Dhondge,
• Yunnus B. Shaikh,
• Vijay B. Ningdale,
• Mayur P. Desai and
• Deekshaputra R. Birhade

Beilstein J. Org. Chem. 2009, 5, No. 4, doi:10.3762/bjoc.5.4

• extensively reported in the literature. This involved the use of Lewis acids like Yb(OTf)3 [23], CuCl2 [24], Mn(OAc)3 [25], Bi(OTf)3 [26], CeCl3·7H2O [27], Cu(OTf)2 [28], FeCl3 [29], BF3·Et2O/Cu(OAc)2 [30], ZrCl4 [31], polymer supported ytterbium reagents [32], TaBr5 [33], ZrCl4 or ZrOCl2 [34]. Baker’s yeast

The first direct synthesis of β-unsubstituted meso- decamethylcalix[5]pyrrole

• Luis Chacón-García,
• Lizbeth Chávez,
• Denisse R. Cacho and
• Josue Altamirano-Hernández

Beilstein J. Org. Chem. 2009, 5, No. 2, doi:10.3762/bjoc.5.2

• be unstable, which probably decreased the yield. To determine whether the reaction proceeds with other Lewis acids, we explored the use of MgCl2, CuCl2, ZnCl2, AlCl3, BiCl3, BiI3, BiPO4, Bi(OTf)3 and Bi(NO3)3 under the conditions described above. Except for MgCl2, which gave none of the byproducts

Shape- persistent macrocycle with intraannular alkyl groups: some structural limits of discotic liquid crystals with an inverted structure

• Sigurd Höger,
• Jill Weber,
• Andreas Leppert and
• Volker Enkelmann

Beilstein J. Org. Chem. 2008, 4, No. 1, doi:10.1186/1860-5397-4-1

• of a solution of 7 in pyridine to a suspension of CuCl and CuCl2 in the same solvent. Column chromatographic purification and repeated recrystallization from ethyl acetate gave the pure macrocycles not contaminated with higher oligomers, as determined by analytical gel permeation chromatography (GPC

• macrocycles with intraannular alkyl chains. i) TMS-acetylene, PdCl2(PPh3)2, CuI, NEt3/THF (97%); ii) K2CO3, MeOH/THF (87%); iii) PdCl2(PPh3)2, CuI, piperidine/THF (37-38%); iv) TMS-acetylene, PdCl2(PPh3)2, CuI, piperidine/THF (76-82%); v) K2CO3, MeOH/THF (89-97%); vi) CuCl, CuCl2, pyridine (12-16%). Synthesis

• , CuCl2, pyridine (28%). Synthesis of macrocycles with adaptable hexyloxy groups. i) PdCl2(PPh3)2, CuI, piperidine/THF (76-78%); ii) Bu4NF, THF (60-99%); iii) PdCl2(PPh3)2, CuI, piperidine/THF (46-48%); iv) TMS (TIPS)-acetylene, PdCl2(PPh3)2, CuI, piperidine/THF (64-98%); v) K2CO3, MeOH/THF or Bu4NF, THF

Solvent- controlled regioselective protection of allyl- 4,6-benzylidene glucopyranosides

• Kerry Ann Ness and
• Marie E. Migaud

Beilstein J. Org. Chem. 2007, 3, No. 26, doi:10.1186/1860-5397-3-26

• was to be used as reaction solvent (Scheme 1). Osborn had reported the regioselective mono-acylation/alkylation of the C-3 hydroxyl of 4,6-O-benzylidene-β-D-glycopyranosides using NaH/CuCl2 in THF [6]. Distinctively, we observed the regioselective benzylation at the C-2 position of the 1-O-allyl-α