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Search for "Michael acceptor" in Full Text gives 78 result(s) in Beilstein Journal of Organic Chemistry.

A short stereoselective synthesis of (+)-(6R,2′S)-cryptocaryalactone via ring- closing metathesis

  • Palakodety Radha Krishna,
  • Krishnarao Lopinti and
  • K. L. N. Reddy

Beilstein J. Org. Chem. 2009, 5, No. 14, doi:10.3762/bjoc.5.14

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  • ], they inhibit HIV protease [8][9], induce apoptosis [10][11][12][13][14][15], and have even proved to be antileukemic [16]. At least some of these pharmacological effects may be related to the presence of the conjugated double bond, which acts as a Michael acceptor [17][18][19][20][21][22][23]. One of
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Published 24 Apr 2009

Efficient 1,4-addition of α-substituted fluoro(phenylsulfonyl)methane derivatives to α,β-unsaturated compounds

  • G. K. Surya Prakash,
  • Xiaoming Zhao,
  • Sujith Chacko,
  • Fang Wang,
  • Habiba Vaghoo and
  • George A. Olah

Beilstein J. Org. Chem. 2008, 4, No. 17, doi:10.3762/bjoc.4.17

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  • )methane only the trans isomer 6l was obtained in an appreciable amount while the cis product was observed only in traces. During our study, we observed that the steric factor affects the addition of the pronucleophile to the Michael acceptor. Substitution at the α-position of the Michael acceptor affects
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Published 21 May 2008

N-1 regioselective Michael- type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate

  • Sławomir Boncel,
  • Dominika Osyda and
  • Krzysztof Z. Walczak

Beilstein J. Org. Chem. 2007, 3, No. 40, doi:10.1186/1860-5397-3-40

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  • hydrophilic polymer gels,[11] has not been considered frequently as a potential Michael acceptor in organic synthesis.[12][13] We have developed an effortless, efficient and useful pathway for the synthesis of 2-hydroxyethyl-3-(uracil-1-yl)propanoates. The products of addition may be further functionalized
  • available, and 5-isobutyrylaminouracil was synthesized as reported previously.[14] Commercially available HEA was applied as the Michael acceptor (Scheme 1). Triethylamine (TEA) (1 equivalent) served as a deprotonating agent. The addition reactions were performed in polar aprotic solvents such as DMF or
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Preliminary Communication
Published 08 Nov 2007
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