Synthesis of meso-substituted dihydro-1,3-oxazinoporphyrins

• Satyasheel Sharma and
• Mahendra Nath

Beilstein J. Org. Chem. 2013, 9, 496–502, doi:10.3762/bjoc.9.53

• of a new series of dihydro-1,3-oxazinoporphyrins in moderate to good yields. These novel porphyrin-dihydro-1,3-oxazine hybrids may be considered as potential candidates not only for biological evaluations but also for the development of newer π-conjugated molecules for various material applications

Multivalent display of the antimicrobial peptides BP100 and BP143

• Imma Güell,
• Rafael Ferre,
• Kasper K. Sørensen,
• Esther Badosa,
• Iteng Ng-Choi,
• Emilio Montesinos,
• Eduard Bardají,
• Lidia Feliu,
• Knud J. Jensen and
• Marta Planas

Beilstein J. Org. Chem. 2012, 8, 2106–2117, doi:10.3762/bjoc.8.237

• -melittin antimicrobial undecapeptide hybrids on a carbohydrate template could provide carbopeptides with improved biological properties. In particular, KKLFKKILKYL-NH2 (BP100) and KKLfKKILKYL-NH2 (BP143) were selected based on their high antibacterial activity against the plant pathogenic bacteria Erwinia

Liquid-crystalline nanoparticles: Hybrid design and mesophase structures

• Gareth L. Nealon,
• Romain Greget,
• Cristina Dominguez,
• Zsuzsanna T. Nagy,
• Daniel Guillon,
• Jean-Louis Gallani and
• Bertrand Donnio

Beilstein J. Org. Chem. 2012, 8, 349–370, doi:10.3762/bjoc.8.39

• addressable 2-D and 3-D arrangements exhibiting high processability and self-healing properties. Herein, we review the developments in the field of discrete thermotropic liquid-crystalline nanoparticle hybrids, with special emphasis on the relationship between the nanoparticle morphology and the nature of the

• tetragonal), and the so-called banana phases formed by bent-core mesogens [30][34][35]. This review will focus on publications that describe the preparation and characterisation of discrete thermotropic liquid-crystalline nanoparticle hybrids. Thus topics such as micellar [36] or lyotropic NPs [37][38

• -/needlelike and platelike shapes, different strategies may be possible for inducing mesophase behaviour in these hybrids. In the case of rod-/needlelike NPs with high aspect ratios, their inherent shape lends itself to the formation of LC phases such as nematics and smectics, subject to the reduction of

Photochemical and thermal intramolecular 1,3-dipolar cycloaddition reactions of new o-stilbene-methylene-3-sydnones and their synthesis

• Kristina Butković,
• Željko Marinić,
• Krešimir Molčanov,
• Biserka Kojić-Prodić and
• Marija Šindler-Kulyk

Beilstein J. Org. Chem. 2011, 7, 1663–1670, doi:10.3762/bjoc.7.196

• hybrids of a number of mesomeric ionic structures (Figure 1). One of the most characteristic reactions of sydnones is the intermolecular 1,3-dipolar cycloaddition. In the presence of acetylenic or ethylenic dipolarophiles, sydnones undergo cycloaddition reactions, which can be induced thermally [4][6][7

Gold-catalyzed heterocyclizations in alkynyl- and allenyl-β-lactams

• Benito Alcaide and
• Pedro Almendros

Beilstein J. Org. Chem. 2011, 7, 622–630, doi:10.3762/bjoc.7.73

• exclusively β-lactam–tetrahydrofuran hybrids 6 in good isolated yields (Scheme 3). Besides total chemocontrol, the reaction was regiospecific and only the five-membered ring ether was formed: The isomeric six-membered ring product was not observed. By contrast, when the cyclization of olefinic α-allenols 5

Novel tetracyclic structures from the synthesis of thiolactone-isatin hybrids

• Renate Hazel Hans,
• Hong Su and
• Kelly Chibale

Beilstein J. Org. Chem. 2010, 6, No. 78, doi:10.3762/bjoc.6.78

• 7701, South Africa 10.3762/bjoc.6.78 Abstract A simple and straightforward synthetic approach to potential anti-infective thiolactone-isatin hybrids led to the discovery of novel tetracyclic compounds which bear a macrocylic motif containing an unusual bridged amide bond. Keywords: bridged amides

• ; hybrids; isatin; tetracycles; thiolactomycin; thiolactone; Introduction Hybrid structures have been found in nature and their synthesis has become a useful drug discovery strategy for new anti-infective agents [1]. Improved pharmacokinetics, therapeutic and toxicity profiles have been reported for

• libraries and concomitantly shortens the time needed to identify potential leads [5]. The focus of this study is on the synthesis of hybrids with monomers derived from natural products thiolactomycin (1) and isatin (2) (Figure 2). The former is a thiolactone antibiotic known for its remarkable selectivity

Synthesis of lipophilic 1-deoxygalactonojirimycin derivatives as D-galactosidase inhibitors

• Georg Schitter,
• Elisabeth Scheucher,
• Andreas J. Steiner,
• Arnold E. Stütz,
• Martin Thonhofer,
• Chris A. Tarling,
• Stephen G. Withers,
• Jacqueline Wicki,
• Katrin Fantur,
• Eduard Paschke,
• Don J. Mahuran,
• Brigitte A. Rigat,
• Michael Tropak and
• Tanja M. Wrodnigg

Beilstein J. Org. Chem. 2010, 6, No. 21, doi:10.3762/bjoc.6.21

• neurological deterioration [23]. Our studies revealed that 1-deoxy-D-galactonojirimycin-lysine hybrids, when carrying an aromatic substituent, such as a dansyl moiety, in its nature a lipophilic aromatic substituent, are potent D-galactosidase inhibitors and also show activity with human lysosomal β

Novel banana-discotic hybrid architectures

• Hari Krishna Bisoyi,
• H. T. Srinivasa and
• Sandeep Kumar

Beilstein J. Org. Chem. 2009, 5, No. 52, doi:10.3762/bjoc.5.52

• cores. Hence these compounds are anticipated to display superior electronic and optoelectronic performance in organic semiconducting devices. Moreover, these hybrids may also display new types of banana phases whose potential applications have been mentioned in the introductory paragraph. With this idea

Synthesis and redox behavior of new ferrocene- π-extended- dithiafulvalenes: An approach for anticipated organic conductors

• Abdelwareth A. O. Sarhan,
• Omar F. Mohammed and
• Taeko Izumi

Beilstein J. Org. Chem. 2009, 5, No. 6, doi:10.3762/bjoc.5.6

• multicomponent electron donor systems by the Wittig–Horner reaction of the respective phosphonate ester 6 with different ferreocenylketones using the modifications introduced onto the reaction. The redox chemistry of the ferreocenylketones and these new π-conjugated hybrids 8, 10 and 11 has been studied using